Crocin Improves the Ethanol-induced Impairment of Learning Behaviors of Mice in Passive Avoidance Tasks.
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概要
- 論文の詳細を見る
The acute effects of crocin and picrocrocin, major components of Crocus Sativus L., on learning and memory performances were investigated using mice in passive avoidance tasks. A single oral administration of crocin had no effect on memory acquisition in normal mice. Oral administration of 30% ethanol (10ml/kg) induced impairment of memory acquisition in step through and step down tests. Oral pre-administration of crocin (50 to 200mg/kg) improved the impairment of memory acquisition in both tests in a dose-dependent manner. Crocin (50 to 200mg/kg) also had beneficial effect on 40% ethanol (10mg/kg, p.o.)-induced memory retrieval deficit in step down test. Picrocrocin, the most abundant component in Crocus Sativus L., did not affect the impairment of memory acquisition and retrieval in step through and step down tests at 50-200mg/kg. These results suggest that crocin has preventive effect on the ethanol-induced impairment of learning and memory.
- 日本学士院の論文
著者
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Sugiura Minoru
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Nishiyama Nobuyoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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SHOYAMA Yukihiro
Department of Chemo-Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kyushu University
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SUGIURA Minoru
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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SHOYAMA Yukihiro
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Kyushu University
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