Basic Fibroblast Growth Factor Ameliorates Rotational Behavior of Substantia Nigral-Transplanted Rats with Lesions of the Dopaminergic Nigrostriatal Neurons.
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概要
- 論文の詳細を見る
Basic fibroblast growth factor (bFGF) was injected with dissociated substantia nigral cells into the striatum of rats prepared by unilateral lesion of the nigrostriatal pathway with 6-hydroxydopamine. The transplanted cells with 5 and 50 ng bFGF reduced the apomorphine-induced rotations by 40 and 30%, respectively, while the decrement of rotations was only 15% in the grafted control without bFGF. Immunohistochemical staining with anti-tyrosine hydroxylase antibody showed that bFGF also tended to increase the number of grafted catecholaminergic neurons along the tracts. In the case of 50 ng bFGF treatment but not 0 or 5 ng bFGF treatment, however, severe gliosis was detected along the grafted region by staining of anti-glial fibrillary acidic protein antibody. These immunohistochemical studies suggested that high-dose bFGF induced extensive gliosis, which might affect the survival of the grafted neurons.
- 公益社団法人 日本薬理学会の論文
著者
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Matsuda Susumu
Basic Research Laboratories Toray Industries Inc.
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Nishiyama Nobuyoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Matsuda Susumu
Basic Research Laboratories, Toray Industries Inc.
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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