Effect of Ginseng Saponins on the Survival of Cerebral Cortex Neurons in Cell Cultures

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概要

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• The effects of nerve growth factor (NGF) and saponins isolated from Panax ginseng C. A. MAYER on the survival of chick and rat embryonic cerebral cortex neurons were examined. Ginsenoside Rg1 (GRg1) exerted a survival-promoting effect on both chick and rat cerebral cortex neurons in cell cultures. Ginsenoside Rb1 (GRb1) also had an effect in the rat and displayed some influence in the chick. NGF alone exerted no effect on both neurons, although it did potentiate the GRb1 effect on chick embryonic cerebral cortex neurons, but did not alter the GRb1 effect on rat embryonic cerebral cortex neurons. NGF did not alter the survival-promoting effect of GRg1 on either chick or rat embryonic cerebral cortex neurons. The other saponins alone or with NGF exertecd no effect on the survival of cerebral cortex neurons in either the chick or rat.

• 公益社団法人日本薬学会の論文
• 1989-02-25

著者

• 齋藤 洋

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 西山 信好

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

• 齋藤 洋

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 西山 信好

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 西山 信好

  Faculty of Pharmaceutical Science

• 氷見 敏行

  Faculty of Pharmaceutical Science, University of Tokyo

• 氷見 敏行

  Faculty Of Pharmaceutical Science University Of Tokyo

• Nishiyama Nobuyoshi

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University

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