インドールアルカロイド及びイリドラクトンの生合成におけるイリダン骨格形成機構
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Four biosynthetic intermediates for non-tryptophan moieties of indole alkaloids, 10-oxogeraniol (27a), 10-hydroxygeranial (27b), 10-oxogeranial (28) and iridodial (3), were isolated from the incubation system of 10-hydroxygeraniol (16) and crude enzyme extracts from Rauwolfia serpentina cell suspension cultures. This finding enabled us to establish the mechanism of iridane skeleton formation from 16 in the biosynthesis of indole alkaloids. Furthermore, a novel type of monoterpene cyclase catalyzing the iridodial (3) formation from 28 in the presence of nicotinamide adenine dinucleotide phosphate (NADPH) was partially purified and characterized. Systematic research has not yet been performed on the biosynthesis of iridolactones. However, feeding experiments of several ^3H-labelled putative precursors to Nepeta cataria and Patrinia gibbosa suggested that some of iridolactones in these plants are biosynthesized via somewhat different route from those for the usual iridoids.
- 公益社団法人日本薬学会の論文
- 1988-05-25
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