Lipase-Catalyzed Resolution of Racemic 1-Acyloxy-2-(p-tolyl)propanes

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概要

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• The acetate (11), propanoate (12), butanoate (13), 2-methylpropanoate (14), hexanoate (15), decanoate (16), and hexadecanoate (17) of (±)-2-(p-tolyl)-1-propanol (2) were predominantly hydrolyzed with lipase to give (S)-(-)-2-(p-tolyl)-1-propanol (2). However, the 2,2-dimethylpropanoate (18), benzoate (19), and phenylacetate (20) of (±)-2 were recovered intact even when the reaction was carried out for 100h. From the viewpoints of enentioselectivity and reaction rate, the racemic ester 11 was found to be the most suitable substrate for the optical resolution of (±)-2.

• 社団法人日本薬学会の論文
• 1993-08-15

著者

• 松本 高志

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• 武田 美雄

  徳島大学総合科学部生物環境資源化学分野

• 武田 美雄

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 寺尾 博充

  徳島大総合科

• 和田 眞

  Faculty Of Integrated Arts And Sciences University Of Tokushima

• 松本 高志

  Department of Applied Material Science, Faculty of Integrated Arts and Science University of Tokushi

• 武田 美雄

  Department of Applied Material Science, Faculty of Integrated Arts and Science University of Tokushi

• 寺尾 博充

  Department of Applied Material Science, Faculty of Integrated Arts and Science University of Tokushi

• 高橋 智子

  Department of Applied Material Science, Faculty of Integrated Arts and Science University of Tokushi

• 和田 眞

  Department of Chemistry, College of General Education University of Tokushima

• Takeda Yoshio

  Faculty Of Integrated Arts And Science The University Of Tokushima

• 高橋 智子

  Department Of Applied Material Science Faculty Of Integrated Arts And Science University Of Tokushim

• Matsumoto Takashi

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

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