Enantioselective Biotransformation of 1-Isopropylnaphthalene in Rabbits

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概要

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• 1-Isopropylnaphthalene (1) was administered orally to rabbits and the following eight metabolites, 2-(1-naphthyl)-2-propanol (7), 2-(1-naphthyl)-1-propanol (8 : R/S=83 : 17), 2-(1-naphthyl)-1,2-propanediol (9 : R/S=40 : 60), 4-isopropyl-1,2-naphthoquinone (10), 4-isopropyl-1-naphthol (11), 4-isopropyl-2-naphthol (12), 5-isopropyl-2-naphthol (13), and 2-(1-naphthyl)propanoic acid (14') as its methyl ester (14 : R/S=52 : 48), were isolated from urine. Among them, three metabolites (8,9,and 14), possessing an asymmetric carbon atom in the molecule, were formed enantioselectively and five metabolites (7,10,11,12,and 13) were formed regioselectively.The presumed metabolic pathways of 1-isopropylnaphthalene (1) in rabbits leading to these metabolites are discussed.

• 社団法人日本薬学会の論文
• 1995-02-15

著者

• 石田 孝

  Hiroshima Institute Of Technology

• 松本 高志

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• 武田 美雄

  徳島大学総合科学部生物環境資源化学分野

• 坂本 美津雄

  Faculty of Integrated Arts and Sciences, University of Tokushima

• 武田 美雄

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• 武田 美雄

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 宗 王子

  Faculty of Integrated Arts and Sciences, The University of Tokushima

• 久保 幾美

  Faculty of Integrated Arts and Sciences, The University of Tokushima

• 宗 王子

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Sakamoto Masafumi

  Nagasaki University School Of Pharmaceutical Sciences

• 久保 幾美

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Takeda Yoshio

  Faculty Of Integrated Arts And Science The University Of Tokushima

• 坂本 美津雄

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• Matsumoto Takashi

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

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