Comparative Study of Circadian Variation in Numbers of Peripheral Blood Cells among Mouse Strains: Unique Feature of C3H/HeN Mice(Miscellaneous)

スポンサーリンク

概要

• 論文の詳細を見る

• We examined strain differences in numbers of blood cells and their circadian rhythms in male Jcl:ICR, BALB/cA, C57BL/6J and C3H/HeN mice. The total numbers of circulating white blood cells (WBCs) were increased during subjective day and night, and the peaks in the active period were common to all strains. However, the number of WBCs in C3H/HeN mice remained lower and plasma levels of corticosterone (CS) were slightly higher throughout the day compared with the other strains. The numbers of circulating red blood cells (RBC) also differed according to strain. The numbers of RBCs, hematocrit (HCT) and hemoglobin (RGB) were considerably lower in C3H/HeN mice compared with the other strains, although mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) were highest among the tested strains. We found that serum erythropoetin (EPO) levels were considerably higher in C3H/HeN mice than in the other three strains. The high EPO level might be related to the unique features of RBCs in C3H/HeN mice. The present observations provide basic information about the numbers of peripheral blood cells and their circadian rhythm in mouse models and also demonstrate a unique feature of C3H/HeN mice.

• 2007-06-01

著者

• Oishi Katsutaka

  産業技術総合研究所 生物時計研究グループ

• Oishi Katsutaka

  Clock Cell Biology Research Group Institute For Biological Resources And Functions National Institut

• Oishi Katsutaka

  Clock Cell Biology Group Institute Of Molecular And Cell Biology National Institute Of Advanced Indu

• HORIE Shuichi

  Department of Clinical Biochemistry, Faculty of Pharmaceutical Sciences, Teikyo University

• Ohkura Naoki

  Clinical Molecular Biology Faculty Of Pharmaceutical Sciences Teikyo University

• ISHIDA Norio

  Clock Cell Biology Research Group, Advanced Industrial Science and Technology

• SEKINE Yuji

  Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University

• ATSUMI Gen-ichi

  Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University

• MATSUDA Juzo

  Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University

• Sekine Yuji

  Clinical Molecular Biology Faculty Of Pharmaceutical Sciences Teikyo University

• Matsuda Juzo

  Clinical Molecular Biology Faculty Of Pharmaceutical Sciences Teikyo University

• Atsumi Gen-ichi

  Clinical Molecular Biology Faculty Of Pharmaceutical Sciences Teikyo University

• Ishida Norio

  Clock Cell Biology Department Of Biological Resources And Functions National Institute Of Advanced I

• Ishida Norio

  Clock Cell Biology Research Group Institute For Biological Resources And Functions National Institut

• Horie Shuichi

  Department Of Clinical Biochemistry Kagawa Nutrition University

• Horie Shuichi

  Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Teikyo University

関連論文

• OE-019 Peripheral Clock Regulates Circadian Thrombomodulin Gene Expression in Vascular Endothelial Cells(Molecular biology, vascular-1 (H) OE4,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Effect of CAWS, a Mannoprotein-β-glucan Complex of Candida albicans, on Leukocyte, Endothelial Cell, and Platelet Functions in Vitro
• The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2
• Strain- and Tissue-Dependent Induction of Plasminogen Activator Inhibitor-1 Gene Expression in Fasted Mice
• CHARACTERISTICS OF ENZYME INDUCTION BY PEROXISOME PROLIFERATORS
• Comparative Study of Circadian Variation in Numbers of Peripheral Blood Cells among Mouse Strains: Unique Feature of C3H/HeN Mice(Miscellaneous)
• SST-2 Tumor Inoculation is a Useful Model for Studying the Anti-Tumor Immune Response in SHR Rats
• INDUCTION OF PEROXISOMAL ENZYMES BY CLOFIBRATE DERIVATIVES
• Light-Induced Phase-Shifting of the Peripheral Circadian Oscillator in the Hearts of Food-Deprived Mice
• EFFECTS OF SOME HYPOLIPIDEMIC AGENTS ON BIOCHEMICAL VALUES AND HEPATIC PEROXISOMAL ENZYMES IN RATS : COMPARISON OF PROBUCOL, CGA, KCD-232,MLM-160,AL-369 AND CLINOFIBRATE WITH CLOFIBRATE
• The Potent Inhibition of Vapiprost, a Novel Thromoboxane A_2 Receptor Antagonist, on the Secondary Aggregation and ATP Release of Human Platelets
• Clock mutant mice with Jcl/ICR background shows an impaired learning ability in water maze, but not in passive avoidance, at the beginning of dark phase
• Circadian clock in Ciona intestinalis revealed by microarray analysis and oxygen consumption
• STUDIES ON PEROXISOMES BY AQUEOUS POLYMER TWO PHASE SYSTEM
• Circadian clock, cancer and lipid metabolism

もっと見る 閉じる

スポンサーリンク