Light-Induced Phase-Shifting of the Peripheral Circadian Oscillator in the Hearts of Food-Deprived Mice

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概要

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• In the present study, we investigated the effect of fasting on photoentrainment of the peripheral circadian oscillator in the mammalian heart. Northern blotting showed that a single light pulse applied at an appropriate time in constant darkness, caused obvious phase-shifting in the circadian expression rhythm of the mammalian clock gene Period2 (mPer2) even in the hearts of food-deprived mice. Fasting did not significantly affect either the phase or the light-induced phase-shifts of the mPer2 rhythm. Although several studies of temporal feeding restriction have indicated that feeding is the dominant timing cue for mammalian peripheral oscillators, our findings suggest that feeding is not essential for mammals to induce phase resetting of the circadian oscillator in the heart.

• 社団法人　日本実験動物学会の論文

著者

• Oishi Katsutaka

  Clock Cell Biology Research Group Institute For Biological Resources And Functions National Institut

• Oishi Katsutaka

  Clock Cell Biology Group Institute Of Molecular And Cell Biology National Institute Of Advanced Indu

• Oishi Katsutaka

  Clock Cell Biology Research Group National Institute Of Advanced Industrial Science And Technology

• Kadota Koji

  Computational Biology Research Center National Institute Of Advanced Industrial Science And Technolo

• SAKAMOTO Katsuhiko

  Neuroscience Institute, Morehouse School of Medicine

• Sakamoto Katsuhiko

  Neuroscience Institute Morehouse School Of Medicine

関連論文

• OE-019 Peripheral Clock Regulates Circadian Thrombomodulin Gene Expression in Vascular Endothelial Cells(Molecular biology, vascular-1 (H) OE4,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2
• Strain- and Tissue-Dependent Induction of Plasminogen Activator Inhibitor-1 Gene Expression in Fasted Mice
• Comparative Study of Circadian Variation in Numbers of Peripheral Blood Cells among Mouse Strains: Unique Feature of C3H/HeN Mice(Miscellaneous)
• SST-2 Tumor Inoculation is a Useful Model for Studying the Anti-Tumor Immune Response in SHR Rats
• Light-Induced Phase-Shifting of the Peripheral Circadian Oscillator in the Hearts of Food-Deprived Mice
• Clock mutant mice with Jcl/ICR background shows an impaired learning ability in water maze, but not in passive avoidance, at the beginning of dark phase
• Circadian clock in Ciona intestinalis revealed by microarray analysis and oxygen consumption

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