SST-2 Tumor Inoculation is a Useful Model for Studying the Anti-Tumor Immune Response in SHR Rats
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概要
- 論文の詳細を見る
Objective: The purpose of the present study was to investigate the relation between the dose of tumor cell inoculation (especially the doses less than minimum required to evoke tumor growth) and the anti-tumor immune system, particularly lymphoblast formation and cytotoxic activity of lyniphcytes. Method: We inoculated rats with various doses of SST-2 tumor cells and examined natural killer (NK) cell activity and lymphoblast formation in vitro. Result: The results showed that the cytotoxicities against SST-2 cells and lymphoblast formation of lymphocytes were enhanced by small dose inoculation of tumor cells that could not induce tumor growth. Conclusion: It was suggested that was lymphocutes play an important role as an anti-tumor immune system at small doses of tumor inoculation, which appears to reflect an early stage of tumor growth in vivo. It was also suggested that SST-2 tumor inoculation might be a useful model for studying the anti-tumor immune response in SHR rats.
- 日本衛生学会の論文
著者
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Oishi Katsutaka
Clock Cell Biology Research Group Institute For Biological Resources And Functions National Institut
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Oishi Katsutaka
早稲田大学 人間科学部
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Oishi Katsutaka
Clock Cell Biology Group Institute Of Molecular And Cell Biology National Institute Of Advanced Indu
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Oishi Katsutaka
Clock Cell Biology Group Institute Of Molecular And Cell Biology National Institute Of Advanced Indu
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Machida Kazuhiko
早稲田大学人間科学部衛生学公衆衛学
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Machida Kazuhiko
Department Of Hygiene And Public Health School Of Human Sciences Waseda University
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NISHIO Naomi
Department of Hygiene and Public Health, School of Human Sciences, Waseda University
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Nishio Naomi
Department Of Hygiene And Public Health School Of Human Sciences Waseda University
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Nishio Naomi
Department Of Biomolecular Science Toho Univ.
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MACHIDA Kazuhiko
Department of Hygiene and Public Health, School of Human Sciences, Waseda University
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