EFFECTS OF SOME HYPOLIPIDEMIC DRUGS ON BIOCHEMICAL VALUES AND ON HEPATIC PEROXISOMAL ENZYMES OF NORMOLIPEMIC RAT
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概要
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Effects of vitamin B_2-butyrate, nicomol, ML-236B, KF 1492 and pantethine, which are hypolipidemic drugs, on biochemical values and on hepatic peroxisomal enzymes of normolipemic rat. 1) Vitamin B_2-butyrate (100 mg/kg) and nicomol (1g/kg) increased carnitine acetyltransferase and D-amino acid oxidase activities, respectively, while these drugs had no influence on body weight, liver weight, serum and liver triglyceride, and serum and liver cholesterol levels. 2) ML-236B (300 mg/kg) had no influence on biochemical values and on the activities of peroxisomal enzymes containing catalase. 3) KF 1492 (300 mg/kg) had no influence on the biochemical values, but an increase in the activities of fatty acyl-CoA oxdizing system (FAOS) and carnitine acetyltransferase (CAT) participating hepatic lipid metabolism was observed. 4) Pantethine (1g/kg) had no influence on the biochemical values, except a little decrease in the growth rate. However, increase by about 10% in the activities of urate oxidase and D-amino acid oxidase was observed. Catalase activity was decreased to 60% of control level. From these results, it is concluded that, in contrast to clofibrate, vitamin B_2-butyrate, nicomol, ML-236B, KF 1492 and pantethine have little influence on the lipid metabolism of normolipemic animal and on the hepatic peroxisomal enzymes, indicating that the action mechanism of these drugs may be different from that of clofibrate and that the participation of hepatic peroxisomes in hypolipidemic activities of these drugs may be little if any.
- 公益社団法人日本薬学会の論文
著者
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Suga Tetsuya
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Suga Tetsuya
Department Of Clinical Biochemistry Tokyo College Of Pharmacy
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Watanabe Takafumi
Department Of Aerospace Engineering Osaka Prefecture University
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy
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Manna Hiromi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy
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SUGA TETSUYA
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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