EFFECT OF PRETREATMENT WITH BUTYLATED HYDROXYTOLUENE (BHT) ON BINDING OF ^<14>C-BHT TO LUNG MICROSOMES
スポンサーリンク
概要
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The effect of pretreatment with BHT on the binding of ^<14>C-BHT to lung microsomes was examined in vitro. The amount of radioactivity bound to microsomal macromolecules significantly decreased by pretreatment of rats with BHT. This decrease was accompanied by a decrement in the content of cytochrome P-450 and in BHT oxidase activity. Furthermore, the behaviour of these components was dependent upon the dose of BHT given. On the other hand, these three components were unchanged in phenobarbital-pretreated rats.
- 公益社団法人日本薬学会の論文
著者
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Suga Tetsuya
Tokyo College of Pharmacy
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Suga Tetsuya
Department Of Clinical Biochemistry Tokyo College Of Pharmacy
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Hiraga Kogo
Department Of Toxicology Tokyo Metropolitan Research Laboratory Of Public Health
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HIRAGA KOGO
Tokyo Metropolitan Research Laboratory of Public Health
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