Morphological Analysis of Corneal Opacity in Shiba Dog with GM1 Gangliosidosis(Anatomy)
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概要
- 論文の詳細を見る
GM1 gangliosidosis is one of the inherited metabolic lysosomal storage disorders characterized by neurological symptoms caused by β-galactosidase deficiency and consequent accumulation of GM1 ganglioside in neuronal cells, Shiba dogs affected with GM1 gangliosidosis have been found to suffer from corneal opacity. In our morphological analysis, keratocyte enlargement was induced by abnormal intracellular accumulation of neutral carbohydrates, resulting in the loss of normal arrangement of collagen fibrils in the opaque cornea was found to be associated with the disorder. We therefore conclude that corneal opacity in this Shiba dog with GM1 gangliosidosis may be caused by neutral carbohydrate accumulation in lysosomes, swelling and dysfunction of keratocytes, and subsequent irregular arrangement of collagen fibrils in the corneal proper substance.
- 2008-09-25
著者
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Hosaka Yoshinao
Department of Veterinary Medicine, Tottori University
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Hosaka Yoshinao
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Hosaka Yoshinao
酪農学園大学 獣医学部獣医解剖学
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Hosaka Yoshinao
Department Of Biosciences School Of Veterinary Medicine Rakuno Gakuen University
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TAKEHANA Kazushige
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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Yamato Osamu
Laboratory of Veterinary Internal Medicine, , Department of Veterinary Clinical Sciences, Graduate S
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UEDA Hiromi
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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Takehana Kazushige
Department Of Veterinary Anatomy Faculty Of Dairy Science Rakuno Gakuen University
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Takehana Kazushige
Department Of Veterinary Anatomy Rakuno Gakuen University
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Ueda Hiromi
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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NAGAYASU Aya
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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TANGKAWATTANA Prasarn
Department of Biomedical Engineering, School of Medicine, Sapporo Medical University
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NAKAMURA Taito
Department of Veterinary Anatomy, Rakuno Gakuen University
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TSUZUKI Keiko
Veterinary Teaching Hospital, Rakuno Gakuen University
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Ueda Hiromi
Department Of Anatomy Nagoya City University Medical School
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Nagayasu Aya
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Yamato Osamu
Kagoshima Univ. Kagoshima
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Tsuzuki Keiko
Veterinary Teaching Hospital Rakuno Gakuen University
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Nakamura Taito
Department Of Veterinary Anatomy Rakuno Gakuen University
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Yamada O
Laboratory Of Clinical Pathology Department Of Veterinary Clinical Sciences Faculty Of Agriculture K
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Tangkawattana Prasarn
Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Khon Kean University
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Tangkawattana Prasarn
Department Of Biomedical Engineering School Of Medicine Sapporo Medical University
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Hosaka Yoshinao
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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YAMATO Osamu
Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University
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YAMATO Osamu
Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University
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