Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in Achilles Tendon
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概要
- 論文の詳細を見る
In order to investigate whether the oral ingestion of collagen peptide affects the extracellular matrix of tendon, two doses (0.2g/kg and 1.0g/kg body weight) were orally administered daily for 56d to a rabbit, and both the size of collagen fibrils and the amount of glycosaminoglycans in the Achilles tendon were measured in comparison with those in a rabbit fed with a control protein, lactalbumin, or water alone. Ingestion of collagen peptide or lactalbumin induced a significant increase in collagen fibril diameter and a decrease in fibril density except for a high dose of lactalbumin compared with the water control. A histogram pattern of fibril diameter in a high dose of collagen peptide showed a peak at 160-180nm, which was not observed in other groups. However the percentage of diameters over 200nm was the lowest in this group but highest in the low-dose group of collagen peptide. The mean fibril diameter and mass average diameter of a high dose of collagen peptide were significantly smaller than those in a low dose. The amount of dermatan sulphate increased in the high-dose groups, while the amount of hyaluronic acid decreased in rabbits fed with collagen peptide or lactalbumin at either dose. These results suggest that the ingestion of collagen peptide affects the size of collagen fibrils and composition of glycosaminoglycans in the Achilles tendon and thus may improve the mechanical properties of the Achilles tendon.
- 日本ビタミン学会の論文
著者
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Hosaka Yoshinao
Department of Veterinary Medicine, Tottori University
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Hosaka Yoshinao
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Hosaka Yoshinao
酪農学園大学 獣医学部獣医解剖学
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Hosaka Yoshinao
Department Of Biosciences School Of Veterinary Medicine Rakuno Gakuen University
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TAKEHANA Kazushige
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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Mafune Naoki
Department Of Clinical Dietary School Of Food Science Rakuno Gakuen University
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Irie Shinkichi
Nippi Research Institute of Biomatrix
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Irie S
Nippi Research Institute Of Biomatrix
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Irie Shinkichi
Research Institute Of Biomatrix Nippi Inc.
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UEDA Hiromi
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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MINAGUCHI Jun
Department of Veterinary Anatomy, School of Veterinary Medicine
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KOYAMA Yohichi
Nippi Research Institute of Biomatrix, Nippi Inc.
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MEGURI Natsuko
Department of Veterinary Anatomy, School of Veterinary Medicine
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KUSUBATA Masashi
Nippi Research Institute of Biomatrix, Nippi Inc.
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HIROTA Arisa
Nippi Research Institute of Biomatrix, Nippi Inc.
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Kusubata Masashi
Research Institute Of Biomatrix Nippi Inc.
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Takehana Kazushige
Department Of Veterinary Anatomy Faculty Of Dairy Science Rakuno Gakuen University
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Takehana Kazushige
Department Of Veterinary Anatomy Rakuno Gakuen University
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Ueda Hiromi
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Minaguchi Jun
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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KOYAMA Yoh-ichi
Nippi Research Institute of Biomatrix, Nippi Inc.
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Ueda Hiromi
Department Of Anatomy Nagoya City University Medical School
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Hirota Arisa
Nippi Research Institute Of Biomatrix Nippi Inc.
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Minaguchi Jun
Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent
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Koyama Yohichi
Research Institute Of Biomatrix Nippi Inc.
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Meguri Natsuko
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Irie S
Nippi Res. Inst. Biomatrix Tokyo Jpn
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Kusubata Masashi
Nippi Research Institute Of Biomatrix
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Minaguchi Jun
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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Hosaka Yoshinao
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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Meguri Natsuko
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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