種々の発癌物質に対するp53ヘテロ欠損CBAマウスの肝発癌感受性(病理学)
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概要
- 論文の詳細を見る
p53ヘテロ欠損[p53(+/-)]および野生型[p53(+/+)]CBAマウスの肝発癌感受性を検討することを目的として,71匹のp53(+/-)および74匹のp53(+/+)CBAマウス(雄,6-12週齢)を用い,実験1ではflumequine(FL)を4,000ないし0ppm混餌投与,あるいは実験開始時にdimethylnitrosamine(DMN)を5mg/kg腹腔内単回投与,実験2ではdi(2-ethylhexy1)-phthalate(DEHP)を6,000ないし0ppm混餌投与,実験3ではphenolphthalein(PhP)を12,000,6,000ないし0ppm混餌投与した.26週間の処置後,すべての生存動物を屠殺した.FL群の肝細胞小増殖巣の発生頻度はp53(+/+)マウスにおいて,その発生個数はp53(+/-),p53(+/+)マウスにおいて対照群に比し有意に増加した.DMN群の肝細胞小増殖巣の発生頻度と発生個数は,対照群に比し軽度増加した.また,FL,DMN群ともに肝細胞小増殖巣の発生頻度,発生個数およびPCNA陽性細胞数比はp53(+/-)とp53(+/+)マウスとの間で有意差は認められなかった.DEHP,PhP群ともに肝細胞小増殖巣の発生頻度や発生個数は対照群に比し有意差は認められなかった.以上の成績より,CBAマウスにおけるp53遺伝子の片側欠損は化学物質による肝発癌誘導を増強しないことが示唆された.
- 社団法人日本獣医学会の論文
- 2002-07-25
著者
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三森 国敏
東京農工大学農学部獣医学科家畜病理学教室:国立医薬品食品衛生研究所病理部
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安原 加壽雄
国立医薬品食品衛生研究所病理部
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安原 加壽雄
国立医薬品食品衛生研究所
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小野寺 博志
国立医薬品食品衛生研究所病理部
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上原 健城
東京農工大学農学部獣医学科家畜病理学教室
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樫田 陽子
東京農工大学農学部獣医学科家畜病理学教室
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渡辺 隆夫
東京農工大学農学部獣医学科家畜病理学教室
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広瀬 雅雄
国立医薬品食品衛生研究所病理部
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広瀬 雅雄
国立医薬品食品衛生研究所 病理
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三森 国敏
東京農工大
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Watanabe Takafumi
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Watanabe Tomomasa
Laboratory Of Experimental Animal Science Graduate School Of Veterinary Medicine Hokkaido University
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小野寺 博志
国立医薬品食品衛生研究所
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三森 国敏
Division Of Pathology National Institute Of Health Sciences
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Watanabe T
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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