Effects of Gonadotropins on the Occurrence of Permanent Changes in the Testis of Mice Given Neonatal Estrogen Injections

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Daily injections of gonadotropins (PMS, HCG or PMS-HCG) for 15 days from the day of birth, 1 I.U. for the first 10 days and 2 I.U. for the following 5 days, resulted in a hypertrophy of interstitial cells in the testes of mice at 15 days of age. The seminal vesicles were highly stimulated by endogenous androgen in these animals. In the testes of the 60-day-old males which had been given daily injections of estradiol-17β(E) for 15 postnatal days, 20μg for the first 10 days and 40μg for the next 5 days, spermatogenesis was arrested or the seminiferous epithelium was severely damaged. In contrast, the testes of those receiving neonatal injections of E and PMS, E and HCG, and E and PMS-HCG were undergoing active spermatogenesis, showing no damages to the seminiferous epithelium. These findings appear to indicate that neonatally injected estrogen is antagonized by androgen secreted from the testes in response to exogenous gonadotropins and, as a consequence, that the gonadotropin secretion from the anterior hypophysis is not affected.
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