Blockage of the Occurrence of Permanent Vaginal Changes in Neonatally Estrogen-Treated Mice by Vitamin A; Parabiosis and Transplantation Studies
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概要
- 論文の詳細を見る
Occurrence of permanent proliferation and cornification of the vaginal epithelium in ovariectomized adult mice which had received neonatal injections of 20μg estradiol-17β(E<SUP>2</SUP>) was prevented by injections of 200IU vitamin A acetate (VA) given simultaneously with E<SUP>2</SUP>. When neonatally E<SUP>2</SUP>-treated mice were parabiotically joined with ovariectomized mice treated neonatally with E<SUP>2</SUP> plus VA, the permanent vaginal changes were suppressed in the E<SUP>2</SUP> parabionts after the period of 97-110 days of union. These permanent changes were also suppressed by transplantation of vaginae from the E<SUP>2</SUP>-treated donors into the E<SUP>2</SUP> plus VA-treated hosts. A possibleme chanism for the degeneration of permanently changed vaginal epithelium is discussed.
- 社団法人 日本内分泌学会の論文
著者
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Iguchi Taisen
Department Of Bio-enviromental Research Center For Integrative Bioscience National Institute For Bas
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Takasugi Noboru
Department Of Biology Yokohama City University
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YASUI TAKANORI
Department of Biology, Faculty of Science, Okayama University
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- Effects of Sex Hormones on Neonatal Mouse Vaginal Epithelium in vitro
- Changes in Ovary Following Unilateral Ovariectomy with or without"Ovarian Fragmentation"in Mice
- Effects of Neonatal Diethylstilbestrol Exposure on the Growth of Mouse Vaginal Epithelial Cells in Serum-Free Collagen Gel Culture(Endocrinology)
- Blockage of the Occurrence of Permanent Vaginal Changes in Neonatally Estrogen-Treated Mice by Vitamin A; Parabiosis and Transplantation Studies
- Different Perinatal Periods of Vitamin A Administration for Prevention of the Occurrence of Permanent Vaginal Changes in Mice Treated Neonatally with Estrogen(Endocrinology)
- Occurrence of Permanent Changes in Vaginal and Uterine Epithelia in Mice Treated Neonatally with Progestin, Estrogen and Aromatizable or Non-Aromatizable Androgens
- Development of the Vaginal Epithelium Showing Estrogen-Independent Proliferation and Cornification in Neonatally Androgenized Mice
- Occurrence of Permanent Anovulation in Mouse Ovaries and Permanent Changes in the Vaginal and Uterine Epithelia Following Neonatal Treatment with Large Doses of 5α-Dihydrotestosterone
- DEVELOPMENTAL EFFECTS IN MAMMALS INDUCED BY ENVIRONMENTAL ENDOCRINE DISRUPTORS
- Ultrastructural Changes in the Testis of Mice Given Neonatal Injections of Estrogen
- Irreversible Lesions in Female Reproductive Tracts of Mice after Prenatal Exposure to Testosterone Propionate
- Inhibitory Effect of Androgen on Induction of Permanent Changes in the Testis by Neonatal Injections of Estrogen in Mice
- Critical Period of Induction by Tamoxifen of Genital Organ Abnormalities in Male Mice : COMMUNICATION : Developmental Biology
- Testicular Damages in Neonatally Estrogenized Adult Mice
- Effects of Continuous Intravenous Infusion of Diethylstilbestrol into Pregnant Mice on Fetus: Testicular Morphology at Fetal and Postnatal Period
- Effects of Gonadotropins on the Occurrence of Permanent Changes in the Testis of Mice Given Neonatal Estrogen Injections
- Occurrence of Lordosis-like Posture in Male and Female Mice Given Manual Stimulation During the Early Period of Anesthesia
- OBITUARY
- Occurrence of polyovular follicles in ovaries of mice treated neonatally with diethylstilbestrol.
- Changes in male genital organs of mice exposed neonatally to tamoxifen.