Different Perinatal Periods of Vitamin A Administration for Prevention of the Occurrence of Permanent Vaginal Changes in Mice Treated Neonatally with Estrogen(Endocrinology)
スポンサーリンク
概要
- 論文の詳細を見る
Estrogen-independent persistent proliferation and cornification of the vaginal epithelium occurred in ovariectomized (OVX) adult mice which had received 7 daily injections of 20 μg 17β-estradiol (E_2) starting on the day of birth. The permanent vaginal changes were suppressed by neonatal injections of 400 IU retinol acetate (VA) given concurrently with E_2. The suppression by VA was also found in adult OVX, neonatally E_2-treated mice receiving VA injections for 7 days beginning on the 2nd, 4th or 6th postnatal day. The histological features and mitotic rate of the vaginal epithelium in neonatally E_2 plus VA-treated mice (E_2 plus VA mice) were similar to those of Entreated mice until 30 days of age. However, the mitotic rate in the vaginal epithelium of E_2 plus VA mice began to decrease after 60 days of age when clear cells appeared in the basal layer. By 120 days, the epithelium became atrophic, indicating a markedly lowered mitotic rate. In addition, mitotic rate of the vaginal epithelium was significantly lowered in adult OVX offspring of mothers given 3 daily injections of 4,000 IU VA from days 16 to 18 of gestation.
- 社団法人日本動物学会の論文
著者
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Tachibana Hiroshi
Department Of Applied Chemistry Graduate Course Of Urban Environmental Sciences Tokyo Metropolitan U
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Tachibana Hiroshi
Department Of Parasitology School Of Medicine Tokai University
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Iguchi Taisen
Department Of Bio-enviromental Research Center For Integrative Bioscience National Institute For Bas
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Iguchi Taisen
Department Of Biology Yokohama City University
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Takasugi Noboru
Department Of Biology Yokohama City University
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IGUCHI Taisen
Department of Basic Biology, Faculty of Life Science, The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5–1 Higashiyama, My
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TAKASUGI Noboru
Department of Biology
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- OBITUARY
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