Inhibitory Effect of Androgen on Induction of Permanent Changes in the Testis by Neonatal Injections of Estrogen in Mice
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概要
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In male mice which had been given 15 daily injections of estradiol-17β(E) from the day of birth, 20μg for the first 10 days and 40μg for the following 5 days, spermatogenesis was permanently inhibited. Both the seminiferous epithelium and the interstitial tissue of the testes were highly deranged in half the number of the animals at 60 days of age. If testosterone propionate (TP), 4-40μg for the first 10 days and 8-80μg for the following 5 days, was injected simultaneously with E, active spermatogenesis was going on in the testes when examined at 60 days, although the testes were smaller than those in the oil controls. The epithelium of the seminal vesicles and ventral prostates was stimulated by endogenous androgen in the mice given E plus TP.
- 社団法人 日本内分泌学会の論文
著者
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Takasugi Noboru
Department Of Biology Yokohama City University
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Furukawa Makoto
Department Of Biosciences Teikyo University
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FURUKAWA MAKOTO
Department of Biology, Faculty of Science, Okayama University
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TAKASUGI NOBORU
Department of Biology, Faculty of Science, Okayama University
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- OBITUARY