EFFECTS OF ANDROGEN AND ESTROGEN ON DNA SYNTHESIS IN IMMATURE RAT PROSTATE
スポンサーリンク
概要
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We investigated the effects of testosterone propionate (T) and/or estradiol (E_2) on the activity of thymidine kinase (TK) and its isozymes and the incorporation of ^3H-thymidine in the prostate of immature rats. The maximum activity of prostatic TK increased approximately 50 times the basal level 48 hr after T administration. Puromycin and actinomycin D inhibited nearly 100% of the increase induced by T administration. The prostatic TK isozymes were separated into 3 types by DEAE-cellulose column chromatography, and the activity of the isozyme eluted with buffer alone was markedly increased in T-treated rats, and this isozyme was suggested to be involved in rapid DNA replication because its activity was not affected by deoxycytidine triphosphate (dCTP). The addition of E_2 quickened the induction of maximum TK activity due to T administration. Autoradiographic examination indicated that T alone induced marked DNA synthesis in prostatic epithelium, and E_2 plus T enhanced DNA synthesis synergistically.
- 日本組織細胞化学会の論文
著者
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Kudo H
Department Of Material And Biological Chemistry Faculty Of Science Ymagata University
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Sakamoto Shinobu
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University
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Kudo Hideki
The Blood Center Tokyo Metropolitan Bokuto General Hospital
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Nakayama Tohru
Department Of Endocrinology Medical Research Institute Tokyo Medical And Dental Universify
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Kudo Hideaki
Department Of Material And Biological Chemistry Faculty Of Science Ymagata University
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Sugiura Y
Department Of Endocrinology Medical Research Institute Tokyo Medical And Dental Universify
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Sugiura Yoshie
Department Of Cell Biology Medical Research Institute Tokyo Medical And Dental University
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KAWASAKI TOHRU
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental Universify
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KASAHARA NORIYUKI
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental Universify
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OKAMOTO RYOHEI
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental Universify
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Sakamoto Shinobu
Department Of Endocrinology Medical Research Institute Tokyo Medical And Dental University
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Kawasaki Tohru
Nihon Tokushu Noyaku Seizo Co. Ltd.
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Okamoto R
Department Of Endocrinology Medical Research Institute Tokyo Medical And Dental Universify
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Okamoto Ryohei
Department Of Endocrinology Medical Research Institute Tokyo Medical And Dental University
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Kasahara Noriyuki
Department Of Endocrinology Medical Research Institute Tokyo Medical And Dental Universify
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KAWASAKI Tohru
Department of Dental Pharmacology, Tohoku Dental University
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