INTERACTION OF ESTROGENS OR ANTIESTROGEN WITH ESTROGEN RECEPTOR IN THE RAT UTERUS (HISTOCHEMICAL APPROACHES TO THE RECEPTORS)

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概要

• 論文の詳細を見る

• The interaction of estrogens with different duration of action or antiestrogen with the estrogen receptor (ER) in adult rat uterus is described. Estradiol-17β (E_2) or nafoxidine (UA; antiestrogen) were injected into the castrated rats. E_2 injection: Cytoplasmic ER (ERc) decreased, whereas nuclear ER (ERn) increased at 4 hr after the injection. Both the ERc and the ERn returned to the control level at 36 hr. UA injection: ERc decreased, whereas ERn increased at 4 hr after the injection. Neither the ERc nor the ERn returned to the control level even at 72 hr. UA induced a long term ER retention in the nucleus, accompanied by a sustained depletion of the ERc. Estradiol dipropionate (ER; long acting estrogen) injection: ERc decreased 1 day after the injection and remained low for 7 days while plasma E_2 was high; then returned to the control level by 14 days. ERn increased 1 day after the injection and continued to be high during the subsequent 14 days. In the present 14-day-experiment, ED inhibited the recycling of the ER from the nucleus to the cytoplasm, but not a synthesis of new receptor.

• 日本組織細胞化学会の論文

著者

• Okamoto Ryohei

  Department Of Endocrinology Medical Research Institute Tokyo Medical And Dental University

• IMAMURA YOSHIHISA

  Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University

• Imamura Yoshihisa

  Department Of Endocrinology Medical Research Institute Tokyo Medical And Dental University

関連論文

• EFFECTS OF ANDROGEN AND ESTROGEN ON DNA SYNTHESIS IN IMMATURE RAT PROSTATE
• EFFECTS OF ANDROGEN ON DNA SYNTHESIS IN IMMATURE RAT UTERI
• INTERACTION OF ESTROGENS OR ANTIESTROGEN WITH ESTROGEN RECEPTOR IN THE RAT UTERUS (HISTOCHEMICAL APPROACHES TO THE RECEPTORS)
• The Size of the Corpus Luteum during Pseudopregnancy and Pregnancy in the Rat

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