Long Term Adrenal Insufficiency Induces Skeletal Muscle Atrophy and Increases the Serum Levels of Active Form Myostatin in Rat Serum(Physiology)
スポンサーリンク
概要
- 論文の詳細を見る
Skeletal muscle wasting is a common symptom in the adrenal insufficiency such as Addison's disease. Although it has been suspected that several cytokines and/or growth factors are responsible for the manifestation of the symptom, the precise mechanisms underlying the phenomenon have so far been poorly understood. Myostatin is predominantly expressed in skeletal muscles and involved in the regulation of skeletal muscle mass. Recently, several reports indicated that myostatin is secreted into the circulation and the increased levels of circulating myostatin is associated with the induction of skeletal muscle wasting in adult animals. We, therefore, hypothesized that the increased levels of circulating myostatin may account for the development of skeletal muscle wasting in adrenal insufficiency. To test the validity of this hypothesis, we compared the serum levels of myostatin in normal with those in bilaterally adrenalectomized (ADX) rats, a model of Addison's disease, by Western blot analysis. The active form of myostatin (13 kDa) was barely detectable in the sera collected either 1 month or 2 month after adrenalectomy, but present at conspicuously detectable levels in those obtained 3 month after the operation, while the total amounts of myostatin proteins (sum of the precursor and the active forms) remained constant at all the time points examined post-operatively. These results are consistent with the hypothesis that the increased serum levels of active form of myostatin protein, induced yet unknown post-translational control mechanisms may be responsible, at least in part, for the muscle wasting associated with the adrenal insufficiency syndromes.
- 社団法人日本動物学会の論文
- 2005-02-25
著者
-
YAMANOUCHI Keitaro
Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
-
NISHIHARA Masugi
Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
-
Yamanouchi K
Waseda Univ. Saitama
-
舘 鄰
Life Science Institute Mitsubishi-kagaku Co. Ltd
-
Tachi C
Azabu Univ. Sagamihara Jpn
-
舘 鄰
東京大学大学院農学生命科学研究科応用動物科学専攻応用遺伝学研究室
-
HOSOYAMA Tohru
Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The Universi
-
Harigaya Toshio
Laboratory Of Functional Anatomy Department Of Life Sciences Faculty Of Agriculture Meiji University
-
Harigaya Toshio
Faculty Of Agriculture Meiji University
-
Harigaya T
Meiji Univ. Kawasaki Jpn
-
Hasegawa T
Japan Racing Horse Assoc. Utsunomiya‐shi Jpn
-
Hasegawa T
Equine Research Institute
-
Yamanouchi K
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
-
Yamanouchi Keitaro
Department Of Veterinary Physiology Veterinary Medical Science The University Of Tokyo
-
Yamanouchi Keitaro
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
-
舘 鄰
麻布大学獣医学部動物応用科学科
-
Nishihara Masugi
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
-
Nishihara Masugi
Department Of Veterinary Physiology Veterinary Medical Science The University Of Tokyo
-
Hosoyama Tohru
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
-
Harigaya T
Department Of Anatomy Faculty Of Medicine Kyoto University
-
Tachi Chikashi
Life Science Institute, Mitsubishi-Kagaku Co. Ltd
-
Yokouchi Kou
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences The University Of T
-
Nishihara Masugi
Department Of Veterinary Physiology The University Of Tokyo
-
Hasegawa Telhisa
Equine Res. Inst. Japan Racing Assoc.
-
Nishihara Masugi
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University Of Tokyo
-
NISHIHARA MASUGI
Department of Physiology, Yokohama City University School of Medicine
-
NISHIHARA Masugi
Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
-
HOSOYAMA Tohru
Department of Biology, Faculty of Science, Graduate School of Science and Technology, Chiba University
関連論文
- Involvement of 20α-Hydroxysteroid Dehydrogenase in the Maintenance of Pregnancy in Mice
- The Effects of GABA on Embryonic Gonadotropin-Releasing Hormone Neurons in Rat Hypothalamic Primary Culture
- 哺乳類の毛皮標本からのDNA抽出ならびに機能遺伝子の回収に関する研究
- ウマ胎子生殖腺におけるインヒビンαサブユニットmRNAの発現とその局在
- Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by sry
- 哺乳類卵子解析のための小規模ウエスタンブロッティング系「マイクロ・ウエスタンブロッティング」の確立
- ブタ卵成熟におけるMPF活性化に対する卵核胞の必要性の検討
- 哺乳類の毛皮標本からのDNA抽出ならびに機能遺伝子の回収に関する研究
- ウマフォリスタチンcDNAのクローニングと雌ウマ生殖器官における遺伝子発見
- Circadian modulation of hepatic transcriptome in transgenic rats expressing human growth hormone
- ヤギ胎盤における20α-水酸化ステロイド脱水素酵素の発現とその役割
- ヤギ20α-水酸化ステロイド脱水素酵素cDNAのクローニング
- リポソーム・ペプチド・DNA複合体は精子ベクター法による遺伝子導入効率を向上する
- 東京大学農学生命科学研究科に保存されているニホンオオカミ (Canis lupus hodophilax Temminck) 剥製標本から回収したアメロゲニン遺伝子(AMELX)エクソンDNAのクローニングとヌクレオチド配列の決定について
- ニホンカモシカ (Capricornis crispus) 精巣上体精子の液体窒素中での凍結保存
- Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses
- Effects of Estrogen on Growth Hormone Pulsatility in Peripheral Blood and Neuropeptide Profiles in the Cerebrospinal Fluid of Goats
- ウマ(サラブレッド)マイオスタチンcDNAのクローニングと血清中マイオスタチン前駆タンパク質の検出
- シバヤギ胎盤から樹立したクローン化培養細胞株CPF-1におけるテロメア長短縮の解析
- 新生ラット視床下部における性ステロイド依存性遺伝子の発現解析
- 性腺刺激ホルモン放出ホルモンニューロンに緑色蛍光タンパク質を発現するトランスジェニックラットの作出
- シバヤギにおけるプロスタグランジンF2αの繰返し投与による不完全性周期の誘起
- Novel Development of Mammary Glands in the Nursing Transgenic Mouse Ubiquitously Expressing WAP Gene
- Genetic Characteristics of Inbred Wuzhishan Miniature Pigs, a Native Chinese Breed
- Regulation of growth hormone pulsatility in female goats : modulation by sex steroids and involvement of neuropeptide Y
- Both PPARγ and C/EBPα are Sufficient to Induce Transdifferentiation of Goat Fetal Myoblasts into Adipocytes
- Expression of Membrane-Type 1 Matrix Metalloproteinase (MT1-MMP) mRNA in Trophoblast and Endometrial Epithelial Cell Populations of the Synepitheliochorial Placenta of Goats (Capra hircus)
- Possible role for the c-ski gene in the proliferation of myogenic cells in regenerating skeletal muscles of rats
- A Transgenic Mouse Model for Investigating the Response of the Upstream Region of Whey Acidic Protein (WAP) Gene to Various Steroid Hormones
- In vitro Studies on PGC or PGC-Like Cells in Cultured Yolk Sac Cells and Embryonic Stem Cells of the Mouse
- Isolation of Satellite Cells from Equine Skeletal Muscle
- ウマ(サラブレッド種)各組織におけるc-ski遺伝子の発現について
- Cell-Cell Contract Down-Regulates Expression of Membrane Type Metalloproteinase-1 (MT1-MMP) in a Mouse Mammary Gland Epithelial Cell Line
- 妊娠中のマウス子宮と胎盤におけるβig-h3 mRNAの動態 : トロフォブラスト侵襲の制御因子としての可能性について
- Possible Mechanisms for the Testis-Mediated Gene Transfer as a New Method for Producing Transgenic Animals
- Production of Transgenic Rats and Mice by the Testis-Mediated Gene Transfer
- hGH Transgenic Rats Expressing Severe Obesity and Effect of Treatment with hGH in a Pulsatile Manner
- Sex Difference and Postnatal Change of Maternal Behavioral Patterns in Juvenile Male and Female Rats(SHORT COMMUNICATION,Reproductive Biology)
- INCIDENCE OF RETRIEVING BEHAVIOR IN JUVENILE FEMALE AND MALE RATS : INFLUENCE OF NEONATAL ANDROGEN(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Inhibitory Effect of Progesterone on Sexual Receptivity in Female Rats : A Temporal Relationship to Estrogen Administration
- Involvement of Prostaglandins in Suppression of Gonadotropin-Releasing Hormone Pulse Generator Activity by Tumor Necrosis Factor-α
- Tumor Necrosis Factor-α Mediates Endotoxin Induced Suppression of Gonadotropin-Releasing Hormone Pulse Generator Activity in the Rat
- Reproductive Phenotypes in Mice with Targeted Disruption of the 20α-Hydroxysteroid Dehydrogenase Gene
- Characterization of GH Pulsatility in Male Shiba Goats : Effects of Postpubertal Castration and KP102
- Expression of Ovarian 20α-Hydroxysteroid Dehydrogenase in Rat Thymus
- EXPRESSION OF 20α - HYDROXYSTEROID DEHYDROGENASE IN RAT THYMUS
- ROLE OF GRANULIN THE PROCESS OF SEXUAL DIFFERENTIATION OF THE RAT BRAIN
- Hypothalamic Gonadotropin-Releasing Hormone Gene Expression during Rat Estrous Cycle
- ELECTROPHYSIOLOGICAL STUDIES ON THE HYPOTHALAMIC GnRH PULSE GENERATOR
- マウス20α-水酸化ステロイド脱水素酵素ゲノムDNAのクローニングとその遺伝子座の決定
- ラット卵巣におけるグラニュリン前駆体蛋白(アクログラニン)の卵子特異的な発現
- マウス20α-水酸化ステロイド脱水素酵素遺伝子のクローニングとその妊娠期におけるmRNA発現
- 周生期ラットにおけるメトキシクロール暴露が成熟後の生殖機能に与える影響
- Prolactin Expresses Differential Effects on Apoptotic Cell Death of Luteal Cells In Vivo and In Vitro
- Splenic Macrophages Can Modify Steroidogenesis of Leydig Cells
- Expression of Ski in the Granulosa Cells of Atretic Follicles in the Rat Ovary
- Long Term Adrenal Insufficiency Induces Skeletal Muscle Atrophy and Increases the Serum Levels of Active Form Myostatin in Rat Serum(Physiology)
- In Vivo Culture of IVF-Bovine Embryos in Murine Oviducts
- Substantial Evidence to Localize the Developmental Origin of Primordial Germ Cells in the Chicken
- Substantial Evidence to Localize the Developmental Origin of Primordial Germ Cells in the Chicken
- Transgenic Mice Overexpressing Foreign Whey Acidic Protein (WAP) Genes Driven by Metallothionein Promoter
- Effects of Transfected Human and Mouse SRY/Sry Genes upon the Expression of Hypothetical SRY-Cascade Genes in Cultured Mouse Sertoli Cell Line, TM-4
- Quantitative Analysis of the Expression of Whey Acidic Protein (WAP) mRNA in the Prolactin-Responsive Mouse Mammary Gland Epithelial Cell Line, HC11
- Expression of Matrix Metalloproteinase-11 (Stromelysin-3) and TIMP-1 Genes in the Placenta and the Uterus during Estrous Cycles and Gestation in the Mouse
- Requirement of Mitogen-Activated Protein Kinase Activation for the Meiotic Resumption of Porcine Oocytes
- Investigation of the fate of Sry-expressing cells using an in vivo Cre/loxP system
- Expression of Matrix Metalloproteinase-11 Genes in Placentae and Uteri of Shiba Goats (Capra hircus)
- Effect of Calcium lonophore A23187 upon the Rate of Leukotriene C_4 Production and the Cellular Morphology in Highly Purified Mouse Peritoneal Macrophages Cultured in vitro : Cell Biology
- Inhibin α-Subunit mRNA Is Expressed in the Corpus Luteum of the Pregnant Mare
- S-V-4 Adipogenic differentiation of skeletal muscle progenitor/stem cells(The Proceedings of the 17th Annual Meetings of Japan Society of Exercise and Sports Physiology Jury 25-26, (Tokyo))
- Myogenic and Adipogenic Properties of Goat Skeletal Muscle Stem Cells
- Role of Serum Myostatin during the Lactation Period
- プロジェステロンの前処置はエストロジェンにより誘導されるラット子宮上皮細胞でのc-ski mRNAの発現ならびに子宮上皮細胞の増殖を抑制する
- Expression and Possible Role of 20α-Hydroxysteroid Dehydrogenase in the Placenta of the Goat
- ヤギ20α-水酸化ステロイド脱水素酵素cDNAのクローニング
- Age-Dependent Changes in Progranulin Expression in the Mouse Brain
- Alteration in Anxiety with Relation to the Volume of the Locus Ceruleus in Progranulin-Deficient Mice
- Roles of Progranulin in Sexual Differentiation of the Developing Brain and Adult Neurogenesis
- In Vivo Gene Transfer of PPARγ Is Insufficient to Induce Adipogenesis in Skeletal Muscle(Physiology)
- ラット卵巣におけるグラニュリン前駆体蛋白(アクログラニン)の卵子特異的な発現
- Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses
- 周生期ラットにおけるメトキシクロール暴露が成熟後の生殖機能に与える影響
- Skeletal Muscles of Transgenic Mice Expressing Human snoN, a Homologue of c-ski
- Morphological Studies on Testicular Development in the Horse
- In vitro Cre/loxP system in cells from developing gonads : Investigation of the Sry promoter
- Survey of Homeobox Genes Expressed in Hemochorial Placentae of Mice (Mus musculus) and in Epitheliochorial/Syndesmochorial Placentae of Shiba Goats (Capra hircus var. Shiba)
- Molecular Cloning of cDNA for Caprine βig-h3, a TGF-β Responsive Gene, and its Expression in the Uterus of Shiba, Goats (Capra hircus var Shiba)
- マウス20α-水酸化ステロイド脱水素酵素遺伝子のクローニングとその妊娠期におけるmRNA発現
- Inhibin α-Subunit mRNA Is Expressed in the Corpus Luteum of the Pregnant Mare
- Involvement of Granulin in Estrogen-Induced Neurogenesis in the Adult Rat Hippocampus
- Involvement of Granulin in Estrogen-Induced Neurogenesis in the Adult Rat Hippocampus
- Age-Dependent Changes in Progranulin Expression in the Mouse Brain
- Satellite Cell Differentiation in Goat Skeletal Muscle Single Fiber Culture
- Myogenic and Adipogenic Properties of Goat Skeletal Muscle Stem Cells
- The Effects of GABA on Embryonic Gonadotropin-Releasing Hormone Neurons in Rat Hypothalamic Primary Culture
- Effects of Estrogen on Growth Hormone Pulsatility in Peripheral Blood and Neuropeptide Profiles in the Cerebrospinal Fluid of Goats
- Changes in Ratios of Phagocytotic Macrophages in the Splenic Adherent Cells during Estrous Cycle and Pseudopregnancy in Rats
- Identification of Whey Acidic Protein (WAP) in Dog Milk
- Establishment of bipotent progenitor cell clone from rat skeletal muscle
- Induction of Ski Protein Expression upon Luteinization in Rat Granulosa Cells without a Change in its mRNA Expression