Effects of Estrogen on Growth Hormone Pulsatility in Peripheral Blood and Neuropeptide Profiles in the Cerebrospinal Fluid of Goats
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概要
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We previously reported that growth hormone (GH) pulses were negatively associated with neuropeptide Y (NPY) profiles in cerebrospinal fluid (CSF) of the third ventricle of Shiba goats. In addition, while most GH pulses were coincident with GH-releasing hormone (GHRH) pulses, there was no correlation between GH and somatostatin (SRIF) levels. The present study was performed to elucidate the relationship between GH pulses and these neuropeptide levels in CSF when estradiol (1.0 mg/head) was subcutaneously administered to ovariectomized goats. CSF and plasma samples were collected every 15 min for 18 h (from 6 h before to 12 h after injection). GH levels in peripheral blood and GHRH, SRIF and NPY levels in CSF were measured by radioimmunoassay. Pulse/trough characteristics and correlations were assessed by the ULTRA algorithm and cross-correlation analysis. Before estradiol was injected, significant coincidence was found between GHRH pulses and GH pulses, and negative coincidence was found between NPY troughs and GH pulses. Six to 12 h after estradiol injection, the amplitude and area under the curve (AUC) of the GH pulses were markedly increased. The duration and AUC of the GHRH pulses in the CSF were also increased, and stronger synchrony of GHRH with GH was observed. In contrast, the baseline of NPY was significantly decreased, and the negative correlation between the GH pulses and NPY troughs disappeared. The parameters of SRIF troughs were not clearly changed. These observations suggest that estrogen enhances the pattern of secretion of GH in the goat via enhancement of GHRH pulses and decrease of NPY levels.
- 2011-04-01
著者
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Yamanouchi K
Waseda Univ. Saitama
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SAKO Ryuji
Animal Resource Science Center, Veterinary Medical Science, The University of Tokyo
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Li J
Animal Resource Science Center The University Of Tokyo
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Mogi Kazutaka
Companion Animal Research Azabu University
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Mogi Kazutaka
Department Of Neuroendocrinology Yokohama City University Graduate School Of Medicine
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Manabe Noboru
Animal Resource Center The University Of Tokyo:research Center. For Food Safety The University Of To
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Yonezawa Tomohiro
Laboratory Of Veterinary Physiology Kitasato University
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Yonezawa Tomohiro
Laboratory Of Veterinary Physiology The University Of Tokyo
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Yamanouchi K
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
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Yamanouchi Keitaro
Department Of Veterinary Physiology Veterinary Medical Science The University Of Tokyo
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Yamanouchi Keitaro
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
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Li Jun
Animal Resource Science Center Graduated School Of Agriculture And Life Science University Of Tokyo
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Nishihara Masugi
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
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Nishihara Masugi
Department Of Veterinary Physiology Veterinary Medical Science The University Of Tokyo
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Yokouchi Kou
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences The University Of T
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Yonezawa Tomohiro
Department Of Veterinary Physiology The University Of Tokyo
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Nishihara Masugi
Department Of Veterinary Physiology The University Of Tokyo
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Manabe Noboru
Animal Resource Science Center Veterinary Medical Science The University Of Tokyo
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Sako Ryuji
Animal Resource Science Center Veterinary Medical Science The University Of Tokyo
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Nishihara Masugi
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Li Jun
Animal Resource Science Center Graduate School Of Agriculture And Life Science University Of Tokyo
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Yonezawa Tomohiro
Department Of Veterinary Physiology Veterinary Medical Science The University Of Tokyo
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NISHIHARA MASUGI
Department of Physiology, Yokohama City University School of Medicine
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NISHIHARA Masugi
Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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MOGI Kazutaka
Department of Animal Science and Biotechnology, Azabu University
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