Effect of Calcium lonophore A23187 upon the Rate of Leukotriene C_4 Production and the Cellular Morphology in Highly Purified Mouse Peritoneal Macrophages Cultured in vitro : Cell Biology

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概要

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• When the highly purified mouse peritoneal macrophages cultured in vitro, were exposed to calcium ionophore. A23187, at a concentration of 0.5μg/ml for 1.5-2.0hr under alkaline conditions (pH 7.6-8.0) of the medium, the rate of leukotriene C_4 (LTC_4) production by these cells was enhanced approximately by 100 times. The amount of LTC_4 produced was measured by assaying the total amount of cysteinyl leukotrienes released into the medium: the newly developed monoclonal antibodies (supplied by Dr. F. Kohen, Dept. Hormone Res. Weizmann Inst., Rehovot Israel), specific to cyteinyl leukotrienes were used for the purpose. Concomitantly, the ionophore transformed the macrophages of rounded cellular shape to assume the strongly elongated cellular morphology. Causal relationship between the two phenomena, however, remains to be investigated.

• 社団法人日本動物学会の論文
• 1989-04-15

著者

• 舘 鄰

  Life Science Institute Mitsubishi-kagaku Co. Ltd

• Tachi C

  Azabu Univ. Sagamihara Jpn

• Tachi Chikashi

  Zoological Institute Faculty Of Science University Of Tokyo

• ZOR URIEL

  Department of Hormone Research, Weizmann Institute of Science

• Zor Uriel

  Department Of Hormone Research Weizmann Institute Of Science

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