Mecbanisms Underlying Regulation of Local Imnrune Responses in the Uterus during Early Gestation of Eutherian Mammals. III. Possible Functional Differentiation of Macrophages Cultured Together with Blastocyst in vitro, with Special Reference to the Cellul

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In the blastocyst-macrophage co-culture of the mouse, we found two major groups of macrophages which were different in the morphology, i.e., the rounded cells, and the elongated cells. The macrophages in direct contact with the embryonic cells, regardless of whether they were trophoblast or ICM cells, assumed invariably rounded cellular shape. Colchicine, cytochalasin B and D induced strong rounding of the macrophage. The rate of synthesis of leukotriene C_4 in those rounded macrophages remained at a low level of the unstimulated cells. Therefore, it was tentatively proposed that in the blastocyst-macrophage co-culture, the rate of production of LTC_4 in the rounded macrophages, might remain at a low level, while in the elongated ones the rate might be enhanced [C. Tachi and U. Zor, Zool. Sci., in press]. On the other hand, tuftsin, a naturally occurring tetrapeptide known to augment phagocytosis as well as capability of antigen presentation in macrophages, raised slightly the rate of LTC_4 Synthesis around the concentration of 60 nM or above. Recently Gupta presented evidence indicating that LTC_4 mediates the initial estrogen-dependent phase of endometrial modification during nidation in mice. While it is strongly suspected that the major source of LTC_4 produced during that period, might be one of the functionally differentiated groups of macrophages in the endometrium, further work is needed to corroborate the view.
社団法人日本動物学会の論文
1990-04-15

Mecbanisms Underlying Regulation of Local Imnrune Responses in the Uterus during Early Gestation of Eutherian Mammals. III. Possible Functional Differentiation of Macrophages Cultured Together with Blastocyst in vitro, with Special Reference to the Cellul

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