Mechanisms Underlying Regulation of Local Immune Responses in the Uterus during Early Gestation of Eutherian Mammals I. Distribution of Immuno-competent Cells which Bind Anti-IgG Antibodies in the Post-nidatory Uterus of the Mouse(Immunology)

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概要

• 論文の詳細を見る

• Crucial gap of knowledge exists concerning the mechanisms of local immune responses elicited by implanting blastocysts during peri-nidatory period of gestation in mammalian uteri. As an approach to the problem, the distribution of immunocytes capable of reacting with anti-IgG antibodies, was examined immuno-histochemically in the post-nidatory uterus of the mouse. Indirect method employing FITC-labelled antibodies as the secondary antibodies, was used to visualize the reacted cells. In the specimens of implantation sites obtained on Day 5, Day 6, and Day 7 of gestation, the FITC-labelled cells were only sporadically found in the decidua (<3% in a specimen of Day 7 implantation site ), while they were numerously detected in the areas of the endometrium located outside the decidua as well as in the myometrium. In the series of the experiments presently described, the decidual cells were not stained with consistent outcome. The mean number of FITC-labelled cells found per single cross section of the implantation site, showed linear increase on semi-log scales during the period ranging from Day 5 to Day 7. The present findings give further support to the hypothesis that the decidua may serve as a barrier during the peri-nidatory period of gestation not only for the efferent but also for the afferent arm of the maternal immune system.

• 社団法人日本動物学会の論文
• 1985-06-15

著者

• Tachi Chikashi

  Zoological Institute Faculty Of Science University Of Tokyo

• Tachi Chikashi

  Zoological Institute, Faculty of Science, University of Tokyo

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• Mechanisms Underlying Regulation of Local Immune Responses in the Uterus during Early Gestation of Eutherian Mammals I. Distribution of Immuno-competent Cells which Bind Anti-IgG Antibodies in the Post-nidatory Uterus of the Mouse(Immunology)

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