Expression of Ski in the Granulosa Cells of Atretic Follicles in the Rat Ovary
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概要
- 論文の詳細を見る
The aim of the present study was to locate Ski protein, a product of cellular protooncogene c-ski, in rat ovaries in order to predict the possible involvement of Ski in follicular development and atresia. First, expression of c-ski mRNA in the ovaries of adult female rats was confirmed by RT-PCR. Then, ovaries obtained on the day of estrus were subjected to immunohistochemical analysis for Ski and proliferating cell nuclear antigen (PCNA) in combination with terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL). Ski was expressed in granulosa cells that were positive for TUNEL, but negative for PCNA, regardless of the size of follicles. Expression of Ski in TUNEL-positive granulosa cells, but not in PCNA-positive granulosa cells, was also verified in immature hypophysectomized rats having a single generation of developing and atretic follicles by treatment with equine chorionic gonadotropin. These results indicate that Ski is profoundly expressed in the granulosa cells of atretic follicles, but not in growing follicles, and suggests that Ski plays a role in apoptosis of granulosa cells during follicular atresia.
- 日本繁殖生物学会の論文
- 2006-12-01
著者
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KIM Hyun
Department of Internal Medicine, Chonnam National University Hospital
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YAMANOUCHI Keitaro
Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
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NISHIHARA Masugi
Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
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Yamanouchi K
Waseda Univ. Saitama
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Yamanouchi K
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
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Yamanouchi Keitaro
Department Of Veterinary Physiology Veterinary Medical Science The University Of Tokyo
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Yamanouchi Keitaro
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
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Nishihara Masugi
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
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Kim Hyun
Department Of Agricultural Biotechnology And Center For Agricultural Biomaterials Seoul National Uni
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Yokouchi Kou
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences The University Of T
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Nishihara Masugi
Department Of Veterinary Physiology The University Of Tokyo
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Kim Hyun
Department Of Agricultural Bio-resources National Academy Of Agricultural Science Rural Development
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Nishihara Masugi
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Kim Hyun
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Kim Hyun
Department of Advanced Material Engineering, Daejeon University, Daejeon 300-716, Republic of Korea
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NISHIHARA MASUGI
Department of Physiology, Yokohama City University School of Medicine
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NISHIHARA Masugi
Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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