Novel Development of Mammary Glands in the Nursing Transgenic Mouse Ubiquitously Expressing WAP Gene
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概要
- 論文の詳細を見る
Although whey acidic protein (WAP) has been suggested to have some biological functions, its true function has not yet been clearly elucidated. We have generated transgenic mice ubiquitously and highly expressing the WAP gene. The pups born from one female among these transgenic mice showed low growth or died during nursing. This transgenic founder showed novel development of the mammary glands, and demonstrated normal parturition and nursing behavior. The mammary glands showed low-distended ductal structures, and poor development of lobulo-alveolar and acinous formations despite normal nursing, while mammary ducts were rather large in comparison with those of normal lactating females. Although this founder was found to be mosaic for transgenesis, it was shown to be a useful animal model for investigating WAP function.
- 社団法人 日本実験動物学会の論文
- 2002-07-01
著者
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NAITO Kunihiko
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tok
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TOJO Hideaki
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tok
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Tojo H
Univ. Tokyo Tokyo Jpn
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Tojo Hideaki
東京大学 農学生命科学研究科応用遺伝学
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Naito K
Univ. Tokyo Tokyo Jpn
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YAMANOUCHI Keitaro
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tok
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Yamanouchi K
Waseda Univ. Saitama
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Tojo Hideaki
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences The University Of T
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Tojo Hideaki
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Tojo Hideaki
Laboratory Of Animal Reproduction
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Ikeda K
Univ. Tokyo Tokyo Jpn
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Naito K
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Naito Kunihiko
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Science University Of Tokyo
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IKEDA Kayoko
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tok
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KATO Minoru
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tok
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Yamanouchi K
Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University
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Yamanouchi Keitaro
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Naito K
Department Of Applied Genetics Graduate School Of Agriculture And Life Science University Of Tokyo
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Naito Kunihiko
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Yokouchi Kou
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences The University Of T
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Naito Kunihiko
Laboratory Of Applied Genetics Department Of Animal Resource Sciences Graduate School Of Agricultura
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Tojo Hideaki
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences The University Of T
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Kato Minoru
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Naito K
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences The University Of T
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Tojo Hideaki
Laboratory Of Applied Genetics Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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