Effect of Ovariectomy on Mammary Gland Expression of TGFα and EGFR mRNAs and its Relation to Mammary Gland Involution in Mice
スポンサーリンク
概要
- 論文の詳細を見る
To understand the relationship between transforming growth factor α (TGFα) and mammary gland involution, changes in the growth of normal and preneoplastic mammary glands, the expression of TGFα and epidermal growth factor receptor (EGFR) mRNAs in the mammary gland, and serum prolactin (PRL) level were examined in 3-month-old virgin SHN mice 4 to 108 days after ovariectomy (OVX). The formation of normal end-buds and preneoplastic hyperplastic alveolar nodules was significantly reduced after 9 days of OVX, associated with the decreased serum PRL level. Both TGFα and EGFR mRNA expression in the mammary glands declined 18 days after OVX. Thereafter, TGFα mRNA tended to increase, while EGFR mRNA continued to decrease. These observations suggest that the decline of both estrogen and PRL play major roles in the mammary gland involution after OVX, and that the decline of EGFR, through which TGFα manifests its effects, play a secondary role in this process.
- 日本繁殖生物学会の論文
著者
-
YAMAMOTO Kazutoshi
Department of Biology, School of Education, Waseda University
-
Nagasawa Hiroshi
Experimental Animal Research Laboratory, Meiji University, Tama-ku, Kawasaki 214-71, Japan
-
Ikezaki Yoshie
Experimental Animal Research Laboratory, Meiji University
-
Ikezaki Yoshie
Experimental Animal Research Laboratory Meiji University
-
Nagasawa H
Experimental Animal Research Laboratory Meiji University
関連論文
- INVOLVEMENT OF D2 DOPAMINE RECEPTOR SUBTYPE IN INHIBITION OF PROLACTIN RELEASE FROM THE BULLFROG PITUITARY GLAND
- IDENTIFICATION OF cDNAS ENCODING THYROTROPIN-RELEASING HORMONE RECEPTOR FROM THE BULLFROG
- MECHANISMS OF TRH-INDUCED PRL RELEASE FROM THE BULLFROG PITUITARY GLAND
- A POSSIBLE ROLE OF STEROIDAL SUBSTANCES EXISTING IN THE ABDOMINAL GLAND OF THE MALE NEWT, CYNOPS PYRRHOGASTER(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- OCCURRENCE OF STEROIDAL SUBSTANCES IN THE ABDOMINAL GLAND OF THE NEWT CYNOPS PYRRHOGASTER(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- STUDIES OF GHRELIN-INDUCED GROWTH HORMONE AND PROLACTIN RELEASE FROM THE BULLFROG PITUITARY(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- NOVEL FUNCTION OF fGRP AND fGRP RELATED PEPTIDES : THEIR EFFECTS ON THE RELEASE OF TSH FROM THE BULLFROG PITUITARY(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- FROG GROWTH HORMONE-RELEASING PEPTIDE-RELATED PEPTIDES : ISOLATION, CHARACTERIZATION, AND BIOLOGICAL ACTIVITIES
- IDENTIFICATION AND BIOLOGICAL ACTIVITY OF A FROG GH-RELEASING PEPTIDE-RELATED PEPTIDE(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- IDENTIFICATION OF NOVEL HYPOTHALAMIC LPXRF-AMIDE PEPTIDES IN THE VERTEBRATE BRAIN
- AGE-ASSOCIATED CHANGES IN PLASMA CONCENTRATIONS OF GROWTH HORMONE(GH), PROLACTIN(PRL), THYROID-STIMULATING HORMONE(TSH) AND THYROXINE(T_4) IN THE GROWTH-RETARDED MOUSE
- Urinary prostasin in humans : relationships among prostasin, aldosterone and epithelial sodium channel activity
- PJ-727 Percutaneous Coronary Intervention for Acute Myocardial Infarction in the Elderly : Comparison on Clinical Outcome between Younger Patients, Septuagenarians and Octogenarians(Coronary revascularization, PCI-17, The 71st Annual Scientific Meeting of
- OJ-102 Coronary Artery Perforations : Incidence, Predictors and Clinical Outcomes : Multicenter Registry in Japan(Coronary revascularization, PCI-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-466 Successful Embolization Protection Using GuardWire System for Acute Myocardial Infarction : Multicenter GuardWire Registry in Japan(Coronary Circulation, Basic/Clinical 4 (IHD) : PJ78)(Poster Session (Japanese))
- OJ-472 Impact of Devices and Technique Improvement on the Clinical Outcome of Percutaneous Coronary Intervention for Chronic Total Occlusions(Angina Pectoris, Clinical 3 (IHD) : OJ58)(Oral Presentation (Japanese))
- OJ-353 Treatment of Totally Occlusive Diffuse In-Stent Restenosis : Multicenter Registry in Japan(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 9 (IHD) : OJ43)(Oral Presentation (Japanese))
- OJ-352 Systematic Complex Stenting Versus Simple Provisional T-stenting for True Bifurcation Lesions(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 9 (IHD) : OJ43)(Oral Presentation (Japanese))
- OJ-180 Cutting Balloon Angioplasty Versus Stenting for Superficial Femoral Artery : Multicenter Registry in Japan(Peripheral Circulation/Vascular Disease 1 (H) : OJ21)(Oral Presentation (Japanese))
- FRS-127 Influence of Diabetes Mellitus in Patients with Long Coronary Lesions Undergoing Percutaneous Coronary Interventions : Multicenter Registry in Japan(Metabolic Syndrome (H) : FRS15)(Featured Research Session (English))
- Percutaneous coronary intervention in octogenarian population : comparison with elderly patients
- Is Stenting without Predilatation Feasible? Multi Center Experience
- Cutting Balloon Angioplasty Versus Rotational Atherectomy for Treatment of Diffuse In-stent Restenosis
- Treatment of Long Coronary Lesions with Stenting and Rotational Atherectomy
- EXPRESSION OF NOVEL ISOFORM OF BULLFROG PROLACTIN RECEPTOR
- Effects of Coffee Cherry on Lactation in Mice: Improvement of Nesting Behavior
- CHANGES IN PLASMA TSH LEVELS DURING AND AFTER METAMORPHOSIS OF THE BULLFROG
- STIMULATION BY VARIOUS HYPOTHALAMIC FACTORS OF THE RELEASE OF IMMUNOASSAYABLE TSHβ FROM THE BULLFROG PITUITARY
- EFFECT OF ARGININE VASOTOCIN ON THE REPRODUCTIVE BEHAVIOR OF THE MALE NEWT, CYNOPS PYRRHOGASTER
- HORMONAL CONTROL OF THE REPRODUCTIVE BEHAVIOR OF THE REDBELLIED NEWT, CYNOPS PYRRHOGASTER
- HORMONAL CONTROL OF RESPONSES TO A FEMALE-ATTRACTING PHEROMONE, SODEFRIN IN THE NEWT, CYNOPS PYRRHOGASTER
- Comparison of Mammary Gland Growth and Some Physiological Parameters in a High Mammary Tumor Strain of SHN Mice and ICR, Most Popular and 'Normal' Mice
- EFFECT OF ESTROGEN AND PROLACTIN ON THE PERCEPTION OF SODEFRIN IN FEMALE NEWTS, Cynops pyrrhogaster
- PRESENCE OF SODEFRIN VARIANT mRNA IN THE ABDOMINAL GLAND OF THE RED-BELLIED NEWT IN NARA DISTRICT(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- INDIVIDUAL AND REGIONAL DIFFERENCES IN PREPROSODEFRIN GENE EXPRESSION IN THE NEWT, CYNOPS PYRRHOGASTER
- A FEMALE-ATTRACTING ACTIVITY OF STEROIDAL SUBSTANCES IN THE ABDOMINAL GLAND OF THE MALE NEWT, CYNOPS PYRRHOGASTER
- SYNTHESIS OF STEROIDAL SUBSTANCES IN THE ABDOMINAL GLAND OF THE NEWT CYNOPS PYRRHOGASTER
- Induction of Male Sexual Behaviors by Administration of Testosterone Using Silastic Tubes in Castrated Male and Female Rats : COMMUNICATION : Behavior Biology
- PHYSIOLOGICAL ROLE OF CALCITONIN IN TELEOST REPRODUCTION
- PACAP AND SOMATOSTATIN INFLUENCE THE RELEASE OF THYROTROPIN FROM THE BULLFROG PITUITARY(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- BISPHENOL A ACTS AS A THYROID HORMONE AGONIST ON THE BULLFROG PITUITARY(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE, VASOACTIVE INTESTINAL POLYPEPTIDE, AND SOMATOSTATIN INFLUNCE THE RELEASE OF THYROTROPIN FROM THE BULLFROG PITUITARY IN VITRO
- NEGATIVE FEEDBACK REGULATION BY THYROID HORMONE OF PITUITARY THYROTROPIN SECRETION IN THE BULLFROG PITUITARY
- MOLECULAR CLONING OF TWO TYPES OF CORTICOTROPIN RELEASING FACTOR RECEPTOR FROM THE BULLFROG HYPOTHALAMUS
- EFFECT OF THYROID HORMONES ON THE RELEASE OF TSH FROM THE BULLFROG PITUITARY CELLS(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- THYROID-STIMULATING HORMONE-RELEASING ACTIVITY OF CORTICOTROPIN-RELEASING FACTOR (CRF) IS MEDIATED THROUGH THE CRF TYPE 2 RECEPTOR(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- MOLECULAR CLONING OF cDNA ENCODING BULLFROG CORTICOTROPIN-RELEASING HORMONE (CRH)(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- DEVELOPMENT OF RADIOIMMUNOASSAY FOR BULLFROG TSHβ SUBUNIT : EFFECT OF TRH ON THE RELEASE OF IMMUNOASSYABLE TSHβ FROM THE BULLFROG PITUITARY(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- POSSIBLE EXISTENCE OF THYROTROPE-STIMULARING FACTOR IN THE BULLFROG HYPOTHALAMUS
- Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice
- Ultrastructural Changes of Endometrium and Myometrium during Development of Adenomyosis in Mice with Ectopic Pituitary Transplants(Endocrinology)
- Normal and Neoplastic Growth of Mammary Glands and Circulating Levels of Prolactin and Growth Hormone in Mouse Whey Acidic Protein Promoter/Human Growth Hormone (mWAP/hGH) Transgenic Mice
- MOLECULAR ANALYSIS OF GALAXIN, A SOLUBLE SKELETAL MATRIX PROTEIN IN THE SCLERACTINIAN CORAL GALAXEA FASCICULARIS(Biochemistry)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Molecular analysis of a protein in the skeletal organic matrix of the hermatypic coral, Galaxea fascicularis(Biochemistry)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- ANALYSIS OF SKELETAL PROTEINS IN THE HERMATYPIC CORAL Galaxea fascicularis(Biochemistry)Proceedings of the Seventy-First Annual Meeting of the Zoological Society of Japan
- ANALYSIS OF PROLACTIN RECEPTOR mRNA EXPRESSION LEVELS AND DISTRIBUTION IN THE ABDOMINAL GLAND OF SEXUALLY DEVELOPED AND UNDEVELOPED MALE NEWTS, CYNOPS ENSICAUDA
- CDNA CLONING OF AN ANDROGENIC GLAND HORMONE FROM TWO SPECIES OF THE TERRESTRIAL ISOPOD, Porcellio scaber AND P. dilatatus(Endocrinology)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Transforming Growth Factor-α mRNA and Epidermal Growth Factor Receptor mRNA Expression in Normal and Neoplastic Mammary Glands of Four Strains of Mice with Different Mammary Tumor Potentials
- The mRNA Expression of Neurocan, a Brain-Specific Chondroitin Sulfate Proteoglycan, in Neoplastic Mammary Glands in Mice
- Mouse TGF_α Gene Expression in Normal and Neoplastic Mammary Glands and Uteri of Four Strains of Mice with Different Potentials for Mammary Gland Growth and Uterine Adenomyosis
- Different Gene Expression of Mouse Transforming Growth Factor α between Pregnant Mammary Glands and Mammary Tumors in C3H/He Mice
- PROLACTIN INDUCES COURTSHIP BEHAVIOR IN THE MALE NEWTS ACTING CENTRALLY THROUGH THE PROLACTIN RECEPTOR(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Effects of Ovariectomy and Prolactin on Mammary Gland Expressions of Transforming Growth Factor α and Epidermal Growth Factor Receptor mRNAs in Mice
- Effect of Ovariectomy on Mammary Gland Expression of TGFα and EGFR mRNAs and its Relation to Mammary Gland Involution in Mice
- STRUCTURE AND ACTIVITY OF ANDROGENIC GLAND HORMONE IN ARMADILLIDIUM VULGARE(Endocrinology)(Proceedings of the Seventieth Annual Meeting of the Zoological Society of Japan)
- HISTOCHEMICAL ANALYSIS BY LECTIN IN COMPARISON WITH IMMUNOHISTOCHEMICAL PROLACTIN STAINING OF PRENEOPLASTIC AND NEOPLASTIC MAMMARY GLANDS IN FOUR STRAINS OF MICE
- RADIOIMMUNOASSAY AND IMMUNOHISTOCHEMISTRY USING AN ANTISERUM AGAINST BULLFROG GHRELIN(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- LOCALIZATION OF ARGININE VASOTOCIN V3/V1b TYPE RECEPTOR IN THE NEWT PITUITARY AND BRAIN
- Stimulation by Proopiomelanocortin-Derived Peptides of LH Release by Bullfrog Dispersed Anterior Pituitary Cells
- INDUCTION OF IMMEDIATE EARLY GENE EGR-1, C-FOS EXPRESSION IN THE NEWT CHOROID PLEXUS AND PARAPHYSIS BY PROLACTIN
- DISTRIBUTION OF PROLACTIN RECEPTOR IN THE NEWT BRAIN(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- CHANGES OF PROLACTIN RECEPTOR mRNA LEVELS IN THE TAIL AND KIDNEY OF METAMORPHOSING BULLFROG LARVAE(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- PROLACTIN PROLONGS COURTSHIP BEHAVIOR BY THE MALE NEWT, CYNOPS PYRRHOGASTER(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- MOLECULAR CLONING OF BULLFROG PROLACTIN RECEPTOR cDNA
- CENTRAL ACTION OF PROLACTIN IN THE INDUCTION OF COURTSHIP BEHAVIOR OF THE MALE NEWT, CYNOPS PYRRHOGASTER
- ABSENCE OF GENITALIN (GONAD-STIMULATING HORMONE)-INDUCED 1-METHYLADENINE PRODUCTION IN OVARIAN FOLLICLE AND TESTICULAR INTERSTITIAL CELLS OF STARFISH GONADS DURING GAMETOGENESIS
- Hematological and Serum Biochemical Values in Pregnant and Postpartum Females of the Squirrel Monkey (Saimiri sciureus)
- INHIBITORY EFFECTS OF ESTROGEN AND BISPHENOL A ON THYROXINE-INDUCED RESORPTION OF BULLFROG TADPOLE TAIL(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Effect of Activin A and Follistatin on the Release of Pituitary Hormones in the Bullfrog Rana catesbeiana(Endocrinology)
- Two Inbred Strains of Mice with High and Low Mammary Tumor Potentials Established from the Same Basal Stock of Swiss Albino (SHN and SLN): History of Mammary Tumorigenesis and Reproduction after the 30th Generation of Full-sib Mating
- Effect of Ovariectomy on Mammary Gland Expression of TGFα and EGFR mRNAs and its Relation to Mammary Gland Involution in Mice
- ANALYSES OF MASCULINIZING PROCESS IN THE FEMALES OF ARMADILLIDIUM VULGARE AFTER IMPLANTATION OF THE ANDROGENIC GLANDS FROM MATURE MALES(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- IMMUNOHISTOCHEMICAL LOCALIZATION AND SPECIES-SPECIFICITY OF ANDROGENIC GLAND HORMONE IN ONISCIDEA(Endocrinology)Proceedings of the Seventy-First Annual Meeting of the Zoological Society of Japan
- EFFECTS OF DANAZOL ON RAT PROSTATE GLAND(Endocrinology)(Proceedings of the Sixty-Second Annual Meeting of the Zoological Society of Japan)
- Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice