Stimulation by Proopiomelanocortin-Derived Peptides of LH Release by Bullfrog Dispersed Anterior Pituitary Cells
スポンサーリンク
概要
- 論文の詳細を見る
Labeling and immunoprecipitation experiments confirmed that three proopiomelanocortin (POMC)-derived peptides, the N-terminal peptide of POMC (NPP), joining peptide (JP) and adrenocorticotropic hormone (ACTH), were released by the bullfrog (Rana catesbeiana) anterior pituitary. The effects of these three peptides on luteinizing hormone (LH) release by bullfrog dispersed anterior pituitary cells were studied. NPP and ACTH, but not JP, enhanced LH release concentration-dependently. Approximately 6 hr elapsed before the gonadotrophs responded to NPP and ACTH by releasing LH, whereas their response to human GnRH (hGnRH) was faster, suggesting that the modes of action of these two peptides and hGnRH differ. These results raise the possibility that NPP and ACTH act as paracrine factors in the bullfrog pituitary to enhance LH release either directly or indirectly.
- 社団法人日本動物学会の論文
著者
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YAMAMOTO Kazutoshi
Department of Biology, School of Education, Waseda University
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KIKUYAMA Sakae
Department of Biology, School of Education, Waseda University
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Kikuyama Sakae
Department Of Biology Faculty Of Science Shizuoka University
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Yamamoto Kazutoshi
Department Of Biology School Of Education Waseda University
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Iwamuro Shawichi
Department of Biology, Faculty of Science, Toho University
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Iwamuro S
Toho Univ. Chiba Jpn
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Iwamuro Shawichi
Department Of Biology Graduate School Of Science Toho University
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Aida Tomomi
Department of Biology, School of Education, Waseda University
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Oguchi Atsuko
Department of Biology, School of Education, Waseda University
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Iwamuro Shawichi
Department Of Biology Faculty Of Science Toho University
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Aida Tomomi
Department Of Biology School Of Education Waseda University
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Oguchi Atsuko
Department Of Biology School Of Education Waseda University
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