Cortactin-Binding Protein 90 (CBP90) Expression in the Mouse Mammary Glands during Prolactin-Induced Lobuloalveolar Development
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概要
- 論文の詳細を見る
We have previously performed suppression subtractive hybridization to identify genes that were induced during prolactin (PRL)-driven lobuloalveolar development of the mammary gland. This suggested that cortactin-binding protein 90 (CBP90), which is known to be a brain-specific protein that binds to cortactin, was expressed under the regulation of PRL in the mammary glands (preliminary observation). In this study, the expression of CBP90 was examined in the mammary glands of mice under manipulated hormonal circumstances. PRL treatment by 9 days of pituitary grafting induced CBP90 expression in the normal mammary glands but not in the cleared fat pads, while cortactin was expressed constitutively in both the normal mammary glands and the cleared fat pads. Unlike milk proteins, longer treatment with PRL (36 days of pituitary grafting) did not increase the expression level of CBP90 mRNA, while it slightly increased the cortactin mRNA level. Mammary CBP90 mRNA expression was induced by pituitary grafting but not by progesterone treatment in PRL-deficient mice, while pituitary grafting induced mammary CBP90 expression in ovariectomized PRL-deficient mice only when estrogen and progesterone were appropriately supplemented to permit the formation of alveolar buds. The CBP90 protein was detected by immunohistochemistry in the luminal epithelium of the alveolar buds and more faintly in the ductal epithelium. Thus, from the unique expression pattern, CBP90 may be useful as a molecular marker for the hormone-stimulated development of mammary alveolar buds.
- 社団法人日本動物学会の論文
- 2002-04-25
著者
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Mori Takao
Department Of Cardiology Miki City Hospital
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Matsuda M
Laboratory Of Reproductive Biology National Institute For Basic Biology
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守 隆夫
東大 理
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Matsuda Manabu
Department of Biological Sciences, Graduate School of Sciences, University of Tokyo
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Imaoka Tatsuhiko
Department of Biological Sciences, Graduate School of Science, University of Tokyo
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Horseman Nelson
Department of Molecular and Cellular Physiology, University of Cincinnati Medical School
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Lockefeer Jason
Department of Molecular and Cellular Physiology, University of Cincinnati Medical School
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Matsuda M
Osaka Univ. Osaka Jpn
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Matsuda Manabu
Department Of Biological Science Graduate School Of Science University Of Tokyo
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Imaoka Tatsuhiko
Department Of Biological Sciences Graduate School Of Science University Of Tokyo:department Of Molec
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Lockefeer Jason
Department Of Molecular And Cellular Physiology University Of Cincinnati Medical School
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Mori T
Inst. Res. And Innovation Tokyo Jpn
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Horseman Nelson
Department Of Molecular And Cellular Physiology University Of Cincinnati Medical School
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Mori Takao
Department Of Biological Science Graduate School Of Science University Of Tokyo
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Mori Takao
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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