Radiation-Induced Mammary Carcinogenesis in Rodent Models: Whats Different from Chemical Carcinogenesis?
スポンサーリンク
概要
- 論文の詳細を見る
Ionizing radiation is one of a few well-characterized etiologic factors of human breast cancer. Laboratory rodents serve as useful experimental models for investigating dose responses and mechanisms of cancer development. Using these models, a lot of information has been accumulated about mammary gland cancer, which can be induced by both chemical carcinogens and radiation. In this review, we first list some experimental rodent models of breast cancer induction. We then focus on several topics that are important in understanding the mechanisms and risk modification of breast cancer development, and compare radiation and chemical carcinogenesis models. We will focus on the pathology and natural history of cancer development in these models, genetic changes observed in induced cancers, indirect effects of carcinogens, and finally risk modification by reproductive factors and age at exposure to the carcinogens. In addition, we summarize the knowledge available on mammary stem/progenitor cells as a potential target of carcinogens. Comparison of chemical and radiation carcinogenesis models on these topics indicates certain similarities, but it also indicates clear differences in several important aspects, such as genetic alterations of induced cancers and modification of susceptibility by age and reproductive factors. Identification of the target cell type and relevant translational research for human risk management may be among the important issues that are addressed by radiation carcinogenesis models.
- Journal of Radiation Research 編集委員会の論文
著者
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Kakinuma Shizuko
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Shimada Yoshiya
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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IMAOKA Tatsuhiko
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protec
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Daino Kazuhiro
Experimental Radiobiology For Children's Health Res. Group Res. Center For Radiation Protection
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NISHIMURA Mayumi
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protec
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IIZUKA Daisuke
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protec
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TAKABATAKE Takashi
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protec
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OKAMOTO Mieko
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protec
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Okamoto Mieko
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Imaoka Tatsuhiko
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Imaoka Tatsuhiko
Department Of Biological Sciences Graduate School Of Science University Of Tokyo:department Of Molec
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Niizuma Daisuke
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Shimada Yoshiya
Experimental Radiobiology For Children's Health Res. Group Res. Center For Radiation Protection
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Iizuka Daisuke
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Nishimura Mayumi
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Nishimura Mayumi
Low Dose Radiat. Eff. Res. Proj. Nirs
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Takabatake Takashi
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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KAKINUMA Shizuko
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
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SHIMADA Yoshiya
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
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OKAMOTO Mieko
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
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IMAOKA Tatsuhiko
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
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TAKABATAKE Takashi
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
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NISHIMURA Mayumi
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
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KAKINUMA Shizuko
Experimental Biology for Children's Health Research Group, National Institute of Radiological Sciences
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