A Susceptibility Locus for Radiation Lymphomagenesis on Mouse Chromosome 16
スポンサーリンク
概要
- 論文の詳細を見る
BALB/cHeA (BALB/c) mice are sensitive to radiation lymphomagenesis, while STS/A (STS) mice are resistant. We have selected a recombinant mouse, R1, with a STS-derived D16Mit165-D16Mit34 segment in the vicinity of the centromere of chromosome 16 among progeny from a (CcS-7/Dem×BALB/c)F_1 x BALB/c backcross. To test the susceptibility to radiation lymphomagenesis, we generated a genetic cross by mating the male and female R1 progeny obtained by 4-6 backcrosses of R1 to BALB/ c. The mice were subjected to 4×1.7 Gy of X-irradiation. Of 120 mice analyzed, 94 developed lymphomas (91, of thymic type; 3, of nonthymic type) within 315 days of observation. The analysis indicated a link between the susceptibility to lymphomagenesis and the marker D16Mit34 on chromosome 16. The mice heterozygous for the BALB/c and STS alleles at D16Mit34 were less sensitive to lymphomagenesis than the mice homozygous at this locus. There was no significant difference in latency among the genotypes. Our study showed the existence of a susceptibility locus for radiation lymphomagenesis on chromosome 16 and revealed aspects of the genetics of lymphoma susceptibility.
- 日本放射線影響学会の論文
著者
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OKUMOTO Masaaki
Deparment of Laboratory Animal Science, Division of Veterinary Sciences, Graduate School of Agircult
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YAMATE JYOJI
Department of Veterinary Pathology, Graduate School of Agricultural Lifesciences
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Okamoto Mieko
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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MORI Nobuko
Department of Applied Bioscience, Research Institute for Advanced Science and Technology, University
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Okumoto M
Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University:research Institut
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Okumoto Masaaki
大阪府立大学 生命環境科学研究科
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Okumoto Masaaki
Res. Inst. Advan. Sci. Technol. Osaka Prefecture Univ.
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Okumoto Masaaki
Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University
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Okumoto Masaaki
Deparment Of Laboratory Animal Science Division Of Veterinary Sciences Graduate School Of Agircultur
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Mori N
Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University:research Institut
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Mori Nobuko
大阪府立大学 生命環境科学研究科
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Mori Nobuko
Department Of Applied Bioscience Research Institute Of Advanced Science & Technology University
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Yamate J
大阪府立大学大学院生命環境科学研究科
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Yamate Jyoji
Department Of Veterinary Pathology Graduate School Of Agriculture And Biological Science Osaka Prefe
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Mori Nobuko
Department Of Applied Bioscience Research Institute For Advanced Science And Technology University O
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Mori Nobuko
Res. Inst. For Advan. Sci. &technol. Osaka Pre-fecture University.
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YAMATE Jyoji
Department of Integrated Structural Biosciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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