Genetic Control of the Radiosensitivity of Lymphoid Cells for Antibody Formation Ability in Mice

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概要

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• To analyze the genetic basis of the relationship between the radiosensitivity of the immune response and radiation lymphomagenesis, we examined the radiosensitivity of lymphoid cells for antibody formation in BALB/cHeA, STS/A, F_1 hybrids, and their recombinant inbred mouse strains. The decrease in the number of plaque-forming spleen cells in BALB/cHeA mice exposed to 3 Gy X-irradiation was more than tenfold that in STS/A mice. The phenotype of radioresistance was dominant over sensitivity. The coincidence between the strain distribution patterns of the genetic markers and radiosensitivities of antibody formation in the various recombinant inbred strains was in the region with the Igh locus on chromosome 12. There was obvious difference between the patterns in the region containing the Ifa locus on chromosome 4 which has been shown to be related to the incidence of radiation-induced lymphomas. These results indicate that the region on chromosome 12 may contain major gene(s) related to radiosensitivity for antibody formation.

• 日本放射線影響学会の論文

著者

• Imai Shunsuke

  Department Of Pathology Nara Medical College

• 奥本 正昭

  大阪府立大学附属研究所応用生体科学部門

• Imai S

  Department Of Pathology Nara Medical University

• Imai Shunsuke

  Second Department Of Pathology Nara Medical University

• 江崎 孝三郎

  大阪府立大学農学部

• HILGERS JO

  Department of Obstetrics and Gynecology, Research Laboratory for Gynecology, Academic Hospital, Free

• 奥本 正昭

  大阪府立大学附属研究所

• 奥本 正昭

  大阪府立大学 農

• MORI NOBUKO

  大阪府立大学附属研究所応用生体科学部門

• HAGA SATOMI

  Department of Pathology, Nara Medical University

• TAKAMORI YASUHIKO

  Department of Veterinary Radiology, College of Agriculture, the University of Osaka Prefecture

• ESAKI KOZABURO

  Department of Laboratory Animal Science, College of Agriculture, the University of Osaka Prefecture

• Imai Shunsuke

  Department Of Pathology Nara City Hospital

• Esaki Kozaburo

  Coll. Agric. Osaka Pref. Univ.

• Esaki K

  Univ. Osaka Prifecture Osaka Jpn

• Esaki Kozaburo

  Central Institute For Experimental Animals

• Esaki Kozaburo

  Department Of Laboratory Animal Science College Of Agriculture University Of Osaka Prefecture

• Hilgers J

  Department Of Obstetrics And Gynecology Academisch Ziekenhuis Vrije Universiteit

• Hilgers Jo

  Department Of Obstetrics And Gynecology Academisch Ziekenhuis Vrije Universiteit

• Haga Satomi

  Department Of Anatomy Nara Medical University

• Haga Satomi

  Department Of Pathology Nara Medical University

• Mori Nobuko

  大阪府立大学 生命環境科学研究科

• Taka-mori Yasuhiko

  Coll. Agric. Osaka Pref. Univ.

• Takamori Yasuhiko

  Laboratory Of Veterinary Radiology Department Of Veterinary Medicine College Of Agriculture Osaka Pr

• Takamori Yasuhiko

  Univ. Of Osaka Pref. School Of Vet. Med. Dept. Of Radiol.

• Imai Shunsuke

  Department Of Chemistry Graduate School Of Natural Science And Technology Kanazawa University

• ESAKI KOZABURO

  Department of Animal Breeding, Faculty of Agriculture, Nagoya University

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