IMMUNOHISTOCHEMICAL STUDIES ON HUMAN BREAST TISSUES WITH ANTIBODIES AGAINST MOUSE MAMMARY TUMOR VIRUS CORE PROTEIN
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概要
- 論文の詳細を見る
An antigen immunologically related to the major core protein (B-p25) of mouse mammary tumor virus (MTV) was identified in Carnoy's fixativetreated human tissue sections by repeated PAP technique. The positive reaction was restricted to the mammary parenchymal cells, and it was completely absent in 42 normal and 20 cancerous tissues other than the breast. Positive findings were obtained in 14/33 normal mature mammary glands, 14/36 cases of mastopathy, 3/12 mammary fibroadenomas and 18/102 mammary carcinomas. The reactivity was not related to the histological types of tumors nor to the age of patients. Antiserum absorption gave support to MTV-specificity of the immunohistochemical reactions observed. It is concluded that normal as well as neoplastic human breast tissues expressed an antigen related to MTV B-p25. However, a B-p25 specific epitope recognized by a monoclonal antibody (8397) could not be detected in those human tissues investigated.
- 日本組織細胞化学会の論文
著者
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螺良 愛郎
関西医科大学 第2病理
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TSUBURA Airo
Department of Pathology II, Kansai Medical University
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UEDA Satoshi
Department of Neurosurgery, Kyoto Prefectural University of Medicine
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Ueda Satoshi
Division Of Pathology Osaka Saiseikai Nakatsu Hospital
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Tanaka Hisako
Institute Of Medical Science Jikei University School Of Medicine
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Tsubura Airo
Kansai Medical Univ. Osaka Jpn
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Tsubura Airo
関西医科大学 病理学第二
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Tsubura Airo
Department Of Pathology 2 Kansai Medical University
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MORII Sotokichi
Department of Pathology, Kansai Medical University
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HATANO TAKEHIKO
Departments of Surgery, Kansai Medical University
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TANAKA HARUTAKA
Institute for Virus Research, Kyoto University
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ZOTTER STEFAN
Institute of Pathological Anatomy, Medical Academy "Carl Gustav Carus"
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HILGERS JO
German Democratic Republic, and Division of Tumor Biology, The Netherlands Cancer Institute
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螺良 愛郎
Department Of Pathology Ii Kansai Medical University
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Tsubura A
Department Of Pathology Kansai Medical University
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Hilgers Jo
Department Of Obstetrics And Gynecology Research Laboratory For Gynecology Academic Hospital Free Un
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Hilgers Jo
Department Of Obstetrics And Gynecology Academisch Ziekenhuis Vrije Universiteit
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Ueda S
Dokkyo Univ. School Of Medicine Tochigi
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Zotter Stefan
Institute Of Pathological Anatomy Medical Academy "carl Gustav Carus
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Tanaka Harutaka
Institute For Virus Research Kyoto University
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Hatano Takehiko
Department Of Surgery Otokoyama Hospital Kansai Medical University
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Hatano Takehiko
Departments Of Surgery Kansai Medical University
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Ueda Shuichi
Department Of Histology And Neurobiology Dokkyo Medical University School Of Medicine
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Morii Sotokichi
Department Of Pathology Kansai Medical School
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Ueda Satoshi
Department Of Neurosurgery Kyoto Prefectural University Of Medicine
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Ueda Satoshi
Department Of Electronic Engineering Faculty Of Engineering Kobe University:(present Address)fujitsu
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Morii Sotokichi
Department Of Pathology Kansai Medica1 University
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