Similarity of GATA-3 Expression between Rat and Human Mammary Glands
スポンサーリンク
概要
- 論文の詳細を見る
The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal mammary glands, fibroadenomas and carcinomas was immunohistochemically compared in female rats and humans. In normal mammary glands of rats and humans, scattered luminal cells in the acini and whole ductal epithelial cells were positive for GATA-3 in the nuclei. No positive cells were detected in rat or human fibroadenomas. In rat and human mammary carcinomas, the nuclei of proliferating luminal-derived cancer cells expressed GATA-3. Therefore, GATA-3 protein is a candidate marker for mammary carcinoma in rats as well as humans.
- 日本毒性病理学会の論文
著者
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Yoshizawa Katsuhiko
Department Of Pathology Ii Kansai Medical University
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Tsubura Airo
Department Of Pathology 2 Kansai Medical University
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Yuri Takashi
Department Of Pathology Ii Kansai Medical University
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Emoto Yuko
Department of Pathology II, Kansai Medical University, 10-15 Fumizono, Moriguchi, Osaka 570-8506, Japan
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Shikata Nobuaki
Division of Pathology, Kansai Medical University Takii Hospital, 10-15 Fumizono, Moriguchi, Osaka 570-8507, Japan
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Kinoshita Yuichi
Department of Pathology II, Kansai Medical University, 10-15 Fumizono, Moriguchi, Osaka 570-8506, Japan
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Emoto Yuko
Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
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Yuki Michiko
Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
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