N-Methyl-N-nitrosourea-induced Retinal Degeneration in Animals
スポンサーリンク
概要
- 論文の詳細を見る
Retinitis pigmentosa (RP) is a human disease characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. Establishment of reliable animal models is essential for better understanding of this disease and approaches to therapeutic intervention. N-Methyl-N-nitrosourea (MNU)-induced retinal degeneration is highly reproducible, and involves photoreceptor cell loss that ends approximately 7 days after a single systemic administration of MNU. Although the triggering mechanisms of pathogenesis are different and the apoptosis cascade may differ from human RP, MNU-induced photoreceptor cell loss is due to apoptosis. Here, we describe disease progression and therapeutic trials of MNU-induced retinal degeneration in animals.
- 日本組織細胞化学会の論文
著者
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TSUBURA Airo
Department of Pathology II, Kansai Medical University
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YOSHIZAWA Katsuhiko
Department of Toxicologic Pathology, Toxicology Research Laboratories, Fujisawa Pharmaceutical Co.,
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Yoshizawa Katsuhiko
Department Of Pathology Ii Kansai Medical University
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Tsubura Airo
Department Of Pathology 2 Kansai Medical University
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Kiuchi Katsuji
Deparments of Ophthalmology, Kansai Medical University
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Moriguchi Kaei
Departments of Pathology and Ophthalmology, Kansai Medical University
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Kiuchi Katsuji
Department Ophthalmology Kansai Medical University
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Moriguchi Kaei
Department Of Pathology Kansai Medical University
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Yoshizawa Katsuhiko
Department Of Pathology Kansai Medical University
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Yoshizawa Katsuhiko
Departments of Pathology, Kansai Medical University : Department of Toxicologic Pathology, Toxicology Research Laboratories, Fujisawa Pharmaceutical Co Ltd
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Tsubura Airo
Departments of Pathology, Kansai Medical University
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