Age-specific and Dose-dependent Retinal Dysplasia and Degeneration Induced by a Single Intraperitoneal Administration of N-Methyl-N-nitrosourea to Rats
スポンサーリンク
概要
- 論文の詳細を見る
The morphologic response of the rat retina at different ages to the various doses of the alkylating agent N-methyl-N-nitrosourea (MNU) was examined. MNU at the dose of 35, 50, 75, 90, and/or 105 mg/kg was injected intraperitoneally (ip) to male and female Sprague-Dawley and Lewis rats at 0, 21, 50, and 150 days of age, and the retinas were examined 7 or 21 days after the treatment. In both strains of rats, regardless of gender, MNU evoked age-specific and dose-dependent retinal lesions. When ≥ 50 mg/kg MNU were administered at day 0, retinal dysplasia characterized by rosette formation was found in the outer neuroblastic/nuclear layer above the continuous lining single layer of pigment epithelial cells. The severity of the lesion was not dose-related. When > 90 mg/kg, > 50 mg/kg and ≥ 35 mg/kg MNU were administered at day 21, 50, and 150, respectively, retinal degeneration characterized by selective photoreceptor cell loss due to apoptosis with disorganized pigment epithelial cells was found in all rats. Thus, the sensitivity of photoreceptor cells in the development of retinal degeneration induced by MNU increased in parallel with aging.
- 日本毒性病理学会の論文
- 1998-06-01
著者
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南部 裕之
関西医科大学 眼科
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山本 大悟
関西医科大学 第2病理
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山本 大悟
Department Of Pathology Ii Kansai Medical University
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南部 裕之
Department Of Pathology Kansai Medical University
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Tsubura A
Department Of Pathology Ii Kansai Medical University
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螺良 愛郎
関西医科大学 第2病理
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TSUBURA Airo
Department of Pathology II, Kansai Medical University
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義澤 克彦
Department of Pathology II, Kansai Medical University
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楊 継紅
Department of Pathology II, Kansai Medical University
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螺良 愛郎
Department of Pathology II, Kansai Medical University
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義澤 克彦
Department Of Pathology Ii Kansai Medical University
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Yoshizawa Katsuhiko
Toxicologic Pathology Drug Safety Research Labs. Astellas Pharma Inc.
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Yoshizawa Katsuhiko
Department Of Toxicologic Pathology Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Tsubura Airo
関西医科大学 病理学第二
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Tsubura Airo
Departments Of Pathology Kansai Medical University
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螺良 愛郎
Department Of Pathology Ii Kansai Medical University
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Tsubura A
Department Of Pathology Kansai Medical University
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Tsubura Airo
2^<nd> Department Of Pathology
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Nambu Hiroyuki
Department Of Ophthalmology Kansai Medical University
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義澤 克彦
Department Of Pathology And General Toxicology Toxicology Research Laboratories Fujisawa Pharmaceuti
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楊 継紅
Department Of Pathology Ii Kansai Medical University
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Yang Jihong
Department Of Pathology Kansai Medical University
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