Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Gliomatosis Peritonei Derived from Ovarian Immature Teratoma
スポンサーリンク
概要
- 論文の詳細を見る
The mechanisms of gliomatosis peritonei, composed exclusively of mature glial tissue implants on the peritoneum or omentum, are not yet understood. In the present study, the expressions of metalloproteinases (MMPs; MMP-1, -2, -3, and -9) and tissue inhibitors of metalloproteinases (TIMPS; TIMP-1 and -2) were examined in ovarian immatureteratomas with and without glial implants to evaluate the roles of MMPs and TIMPs in gliomatosis peritonei. The immunostaining showed a high expression of MMP-1 in the glial fibrillary acidic protein (GFAP)-positive cells in the glial implants, and in the primary immature teratomas regardless of the existence of gliomatosis peritonei. A weak expression of MMP-2 was seen in both primary and implant sites in the case with gliomatosisperitonei. but not in the cases without glialimplants. In contrast, a high TIMP-2 expression was seen in the glial cells in the cases without gliomatosis peritonei but was absentin the primary as well as peritoneal implantsin the case with gliomatosis peritonei. The expressions of MMP-3, MMP-9, and TIMP-1 were universally negative. These results suggest that the loss of TIMP-2 plays a crucial role in the development of glial implants of ovarian immature teratoma.
- 日本組織細胞化学会の論文
著者
-
Tsubura A
Department Of Pathology Ii Kansai Medical University
-
螺良 愛郎
関西医科大学 第2病理
-
TSUBURA Airo
Department of Pathology II, Kansai Medical University
-
Kiyozuka Yasuhiko
Department of Pathology II, Kansai Medical University
-
UEMURA Yoshiko
Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University
-
SENZAKI Hideto
Department of Pathology II, Kansai Medical University
-
Muraoka Yasunori
Department of Obstetrics and Gynecology, Kurume University School of Medicine
-
Imamura Kazuo
Department of Obstetrics and Gynecology, Kurume University School of Medicine
-
Yakushiji Michiaki
Department of Obstetrics and Gynecology, Kurume University School of Medicine
-
義澤 克彦
Department Of Pathology Ii Kansai Medical University
-
Tsubura Airo
関西医科大学 病理学第二
-
Tsubura Airo
Department Of Pathology 2 Kansai Medical University
-
Tsubura Airo
Departments Of Pathology Kansai Medical University
-
Senzaki H
Department Of Pathology Ii Kansai Medical University
-
Senzaki Hideto
Department Of Pathology Kansai Medical University
-
Senzaki Hideto
Department Of Pathology Ii Kansai Medical University
-
Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
-
Uemura Yoshiko
Department Of Clinical Science And Laboratory Medicine Kansai Medical University
-
螺良 愛郎
Department Of Pathology Ii Kansai Medical University
-
Tsubura A
Department Of Pathology Kansai Medical University
-
Tsubura Airo
2^<nd> Department Of Pathology
-
Kiyozuka Yasuhiko
Department Of Pathology Ii Kansai Medical University
-
Imamura Kazuo
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
-
Uemura Yoshiko
Departments Of Pathology Kansai Medical University
-
Uemura Yoshiko
Department Of Diagnostic Pathology Kansai Medical University Hirakata Hospital
-
Muraoka Yasunori
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
-
Kiyozuka Yasuhiko
Department Of Pathology Kansai Medical University
-
Senzaki Hideto
Departments Of Pathology Kansai Medical University
-
YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
-
Imamura Kazuo
Department of Industrial Chemistry, Kyoto University
関連論文
- Eosinophilic cytoplasmic inclusions in papillary renal cell carcinoma
- Basal cell carcinoma arising from a keratinous cyst of the skin : a case report and review of the literature
- II-B-25 Nicotinamide regulates N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis through poly (ADP-ribose) polymerase-1 signaling pathway in Sprague-Dawley rats(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Malignant rhabdoid tumor of the liver : Case report and literature review
- Immunohistochemical profiles of Mallory body by a panel of anti-cytokeratin antibodies
- Serous microcystic adenoma (glycogen-rich cystadenoma) of the pancreas : Study of 11 cases showing clinicopathological and immunohistochemical correlations
- Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey
- Mucinous carcinoma of the breast with neuroendocrine differentiation
- Time-specific occurrence of alopecia in neonatal C_BL mice treated with N-methyl-N-nitrosourea and the therapeutic efficacy of tacrolimus hydrate
- 22D-09-2 Mechanism of N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in SD rat : regulation of Bcl-2 family and caspase family.