CISPLATIN, ADRIAMYCIN AND IFOSFAMIDE-BASED COMBINATION CHEMOTHERAPY FOR GYNECOLOGICAL CANCERS DERIVED FROM THE EXTENDED MULLERIAN SYSTEM
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概要
- 論文の詳細を見る
女性の***癌を究極的にはcoelomic epitheliumを発生母組織とする腫瘍の一群としてとらえると, これらの腫瘍にはある程度, 共通の抗癌剤感受性が存在するのではないかと期待される. この概念からさまざまな種類の婦人科悪性腫瘍患者70例に対しPAI (cisplatin, adriamycin, ifosfamide)を主体とする化学療法を施行し, その有用性を検討した. 評価可能な25例(腟癌: 1, 頚癌: 10, 体癌: 2, 卵巣癌: 6, 腹膜癌: 3, 肉腫: 3)のうち13例には放射線やPAC (cisplatin, adriamycin, cyclophosphamide)による前治療が施されていたが, 奏効率96%(24/25) (PR : 20, CR : 4)が得られた. CR例では子宮肉腫, 再発子宮頚癌各1例が注目された. 測定可能病変を有さない45例(頚癌: I, II期10, III期3, 体癌: 0, I, II期8, III, IV期6, 卵巣癌: I, II期13, III期5)では最高975日の観察期間中, 生存率は93%(42/45)であり, II期以上の症例では31例, すべてが無病状態を維持している. 副作用として60例(86%)にgrade 4の骨髄機能障害が出現したが, 回復可能であった. 以上よりprimary (腟, 子宮), secondary (卵巣表層上皮, 腹膜) Mullerian system由来の腫瘍群に対してPAIを主体とする化学療法は有用な治療法であると考えられた.
- 社団法人日本産科婦人科学会の論文
- 1990-02-01
著者
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Yakushiji Michiaki
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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Nishida Takashi
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine a
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Nishida Takashi
Department Of Biochemistry And Molecular Dentistry Okayama University Graduate School Of Medicine An
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NAGASUE Naoki
Department of Obstetrics and Gynecology, National Kokura Hospital
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IZUMI Shigeki
Department of Obstetrics and Gynecology, National Kokura Hospital
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Izumi Shigeki
Department Of Obstetrics And Gynecology National Kokura Hospital
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Nagasue Naoki
Department Of Obstetrics And Gynecology National Kokura Hospital
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SAKIHAMA Hideki
Department of Obstetrics and Gynecology, National Kokura Hospital
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Sakihama Hideki
Department Of Obstetrics And Gynecology National Kokura Hospital
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Nishida Takashi
Department Of Obstetrics And Gynecology School Of Medicine Kurume University
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