A Sequential Immunosuppressive Treatment with Mizoribin (Bredinin) plus Cyclosporin A on the Subrenal Capsule Assay.
スポンサーリンク
概要
- 論文の詳細を見る
To minimize immunological interferences on the subrenal capsule (SRC) assay, a new immunosuppressor, mizoribin (MZB: Bredinin) alone or combined with cyclosporin A (ScA) was evaluated by an experimental SRC assay system using a rat ovarian cancer tissue. Daily applications of MZB (200 mg/kg) for 7 days following the xenograft of cancer tissue were insufficient to suppress immunological reactions of the recipient mice, and all the grafted cancer tissues were rejected. Although CsA monotreatment (60mg/kg of CsA given daily for 7 days) successfully suppressed the host immune reaction, enhanced toxicities of CsA in combination with anticancer agents caused high lethal rate of host mice during the experimental chemotherapy. Sequential use of CsA on day 0 to day 2 followed by MZB on day 3, 5 and 7 brought the most favorable results with minimal host reactions and toxicities. An anticancer screening test using the modified SRCA accurately reflected the results of experimental chemotherapy against the rat ovarian cancer. The results suggest that the sequential treatment of MZB and CsA is a feasible immunosuppressive treatment which minimizes immunological interferences with SRC assay chemoscreening test.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Ushijima Kimio
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Nishida Takashi
Department Of Biochemistry And Molecular Dentistry Okayama University Graduate School Of Medicine An
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Oda Takaaki
Department Of Obstetrics And Gynecology School Of Medicine Kurume University
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Sugiyama Toru
Department Of Chemical Engineering Kyoto University
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ODA TAKAAKI
Department of Obstetrics and Gynecology, National Kokura Hospital
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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USHIJIMA KIMIO
Department of Gynecology, Kurume University School of Medicine
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USHIJIMA KIMIO
Department of Obstetrics and Gynecology, National Kokura Hospital
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