POLYCHLOROBIPHENYLS (PCB) INDUCED FETOPATHY:II. EXPERIMENTAL STUDIES : POSSIBLE PLACENTAL TRANSFER OF POLYCHLOROBIPHENYLS IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Four cases of polychlorobiphenyls (PCB) induced fetopathy were described in the previous paper as the part one of this report. The following experimental studies were performed to confirm the possibility of placental transfer of polychlorobiphenyls in pregnant rats, and to elucidate the pathogenesis of the fetopathy. The incidence of maternal death and the abortion increased in proportion to the amount of chlorbiphenyls administered to the mother rat, and histological changes were observed mainly in the liver and in the kidney of the mother. Although, neither external malformation nor abnormal histological findings were noted in the fetus of the rat, <SUP>3</SUP>H-labeled polychlorobiphenyls administered in mother rats were detected in the placenta, amnion and in the whole body of the fetus. The above experimental studies suggest us that the fetopathy obsered in human could be caused by placental transfer of polychlorobiphenyls.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Yamashita Fumio
Department Of Food Science And Technology Faculty Of Agriculture Nagoya University
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Ito Yushi
Department Of Neonatology National Center For Child Health And Development
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Matsumoto Masato
Department Of Neurosurgery Fukushima Medical University
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Takahashi Kenichi
Department Of Anatomy
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Hayashi Masao
Department Of Astronomy Graduate School Of Science The University Of Tokyo
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FUNATSU IICHIRO
Department of Pediatrics, Kurume University School of Medicine
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KATO TOSHI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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TSUGAWA SHIN
Department of Pediatrics, Kurume University School of Medicine
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FUNATSU TAKAKO
Department of Pediatrics, Kurume University School of Medicine
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YOSHIKANE TAKASHI
Department of Pediatrics, Kurume University School of Medicine
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TUDA HIROFUMI
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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ARIMA AKIO
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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SHIMOMURA MASANORI
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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MIYAHARA MICHIYOSHI
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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ADACHI MORITAKE
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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TASHIRO YASUNOBU
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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YAMASHITA FUMIO
Department of Child Health, Kurume University School of Medicine
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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MATSUMOTO MASATO
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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Shimomura Masanori
Department of General Thoracic Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan
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Ito Yushi
Department of Health Science, Kumamoto Health Science University
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