Fenamates Potentiate the α_1-Adrenoceptor-Activated Nonselective Cation Channels in Rabbit Portal Vein Smooth Muscle
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概要
- 論文の詳細を見る
The agonistic action of fenamates on the α<SUB>1</SUB>-adrenoceptor-activated cationic current (I<SUB>cat</SUB>) in rabbit portal vein smooth muscle was investigated with the whole-cell patch clamp technique. At −50 mV, the fenamates (100-500 μM) increased I<SUB>cat</SUB> dose-dependently, up to several fold. This increase was not accompanied by changes in the reversal potential and strongly inhibited by 500 μM Cd<SUP>2+</SUP> or 10 mM procaine. The enhancing effect of fenamates was also observed on the cationic current activated by intracellularly applied GTPγS. These results suggest that fenamates may be useful as a new class of activator for receptor-operated cation channels in smooth muscle.
- 社団法人 日本薬理学会の論文
- 1996-01-01
著者
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Ito Y
Gifu Univ. School Of Medicine Gifu Jpn
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Inoue Ryuji
Department Of Pharmacology Faculty Of Medicine Kyushu University
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Ito Yushi
Department Of Neonatology National Center For Child Health And Development
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Inoue Ryuji
Department Of Pharmacology Faculty Of Medicine Kyusyu University
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Yamada Kazunori
Department Of Applied Molecular Chemistry College Of Industrial Technology Nihon University
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Yamada K
Fukuoka Univ. Fukuoka Jpn
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WANIISHI Yoshiki
Department of Pharmacology, Faculty of Medicine, Kyusyu University
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Waniishi Yoshiki
Department Of Pharmacology Faculty Of Medicine Kyusyu University
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YAMADA Kazunori
Department of Applied Biochemistry, Hiroshima University
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Ito Yushi
Department of Health Science, Kumamoto Health Science University
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