EXPERIMENTAL STUDIES ON THE MORPHOLOGIC CHANGES OF THE ENDOMETRIUM FOLLOWING ESTROGEN AND PROGESTERONE ADMINISTRATION

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Effects of estrogen and progesterone were investigated in rats with particular reference to morphological changes of the endometrium, using commercially available estrogen and progesterone preparations, with the results which may be briefly summarized as follows: 1. Eighty-five (74%) of a series of 115 rats treated with estrogens showed infranuclear vacuolation of the endometrial glandular epithelium. This microscopic feature seems to serve as a reliable morphologic index to endometrial response to estrogen priming. 2. A histologic change suggestive of squamous type metaplasia was considerably high in incidence in the endometrium of the uterine horns of estrogen-treated rats. That no reserve cell-like cells were found in the region of transformed epithelium where glandular epithelial cells were noted to be enlarged and flattened with contiguous squamous epithelium-like cells, suggests a direct metaplasia of endometrial epithelia of the corn uteri. 3. Estrogens have proven to increase the permeability of capillary blood vessels. 4. Administration of a progesterone preparation failed to bring about any conspicuous endometrial change in animals primed with estrogen or in those without estrogen priming, under the described experimental conditions.
久留米大学医学部 The Kurume Medical Journal 編集部の論文