Therapeutic and staging operations for endometrial carcinomas.
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概要
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A staging error can lead to a treatment failure in the management of patients with malignant diseases. The actual progression of endometrial carcinoma was postopertaively examined in twenty patients with clinical stage II disease classified by FIGO (International Federation of Gynecology and Obstetrics) criteria. In seven of 20 patients (35%), extrauterine lesions were revealed at surgery. These seven stage-up tumors included three grage 3 endometrioid cancers, three uterine papillary serous carcinomas (UPSC) and one grade 2 endometrioid tumor with deep myometrial invasion. The sites of the extrauterine lesions were determined. The grade 2 cancer was associated with parametrial invations and positive pelvic lymph nodes. One grade 3 endometrioid tumor and two UPSCs had positive periaortic lymph nodes. Omental involvements were revealed in one grade 3 cancer and two UPSCs, indicating that the pattern of spreading of endometrial cancer with a malignant histology is similar to the spreading of ovarian cancer. Since the both endometrium and ovarian surface epithelium have a common histologic origin in the early embryonic stage, a similar biological characteristics of these tumors are suggested. From the results, it is recommended that a radical hysterectomy with periaortic lymph node dissection, omentectomy and peritoneal washing cytology be performed for endometrial cancer with a malignant histology or deep myometrial invasion to obtain the actual staging which is necessary for maximal curative potential.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Nishida Takashi
Department Of Biochemistry And Molecular Dentistry Okayama University Graduate School Of Medicine An
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Sugiyama Toru
Department Of Chemical Engineering Kyoto University
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SUGIYAMA TORU
Department of Obstetrics and Gynecology, School of Medicine, Kurume University
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RE FRANCESCO
Oncologia Chirurgica Ginecologica, Istituto Nazionale Tumori
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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