Improvement of Congestive Heart Failure after Octreotide and Transsphenoidal Surgery in a Patient with Acromegaly
スポンサーリンク
概要
- 論文の詳細を見る
A 59-year-old man was admitted because of congestive heart failure. He was suspected to have acromegaly, and magnetic resonance imaging revealed a pituitary macroadenoma. Endocrine examination revealed elevated plasma levels of growth hormone (GH) and insulin-like growth factor (IGF)-1, and an oral glucose tolerance test failed to suppress plasma GH levels, consistent with the diagnosis of GH-producing pituitary tumor. Treatment with octreotide, followed by transsphenoidal surgery resulted in normalization of plasma GH/IGF-1 levels, accompanied by the improvement of cardiac function. Thus, it is suggested that excess GH/IGF-1 axis is involved in the development of acromegaly-related cardiomyopathy in the present case.
著者
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Izumiyama Hajime
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Doi Masaru
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Tsuchiya Kyoichiro
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Akaza Itaru
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Hirata Yukio
Department Of Anatomy And Embryology Tokyo Metropolitan Institute For Neurosciences:(present)departm
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Yoshimoto Takanobu
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University
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Sugiyama Toru
Department Of Chemical Engineering Kyoto University
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SUGIYAMA Toru
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
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Akaza Miho
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
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