Type 1 Diabetes Mellitus and Drug-resistant Epilepsy : Presence of High Titer of Anti-Glutamic Acid Decarboxylase Autoantibodies in Serum and Cerebrospinal Fluid
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概要
- 論文の詳細を見る
A 55-year-old man who was diagnosed as having type 1 diabetes mellitus (DM) at the age of 50 years was started on insulin therapy. At 54 years old of age, he suddenly developed complex partial seizures, which frequently occurred despite intensive anti-epileptic drug therapy. Neurological examination on admission revealed hyporeflexia in bilateral upper and lower extremities without any muscle rigidity, painful spasm or cerebellar ataxia. Laboratory examination showed poor glycemic control with increased glycated hemoglobin levels. Positive anti-thyroglobulin antibodies and anti-thyroid peroxidase (TPO) antibodies and slight elevation of TSH levels are consistent with subclinical hypothyroidism due to Hashimoto’s thyroiditis. A high titer of anti-glutamic acid decarboxylase (GAD) antibodies was detected in the patient’s serum and cerebrospinal fluid (CSF). Electroencephalography showed temporal spikes, consistent with complex partial seizure. This is a very rare case presenting with concomitant type 1 diabetes and drug-resistant epilepsy associated with high titers of circulating and CSF anti-GAD antibodies.
- 社団法人 日本内科学会の論文
- 2005-11-01
著者
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MINAMI ISAO
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate Sch
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IZUMIYAMA HAJIME
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate Sch
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DOI MASARU
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate Sch
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HIRATA YUKIO
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate Sch
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Hirata Y
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Minami Isao
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Izumiyama Hajime
東京医科歯科大学 大学院内分泌糖尿病代謝内科
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Izumiyama Hajime
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Doi Masaru
東京医科歯科大学 大学院内分泌糖尿病代謝内科
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Doi Masaru
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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YOSHIMOTO TAKANOBU
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate Sch
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Hirono Yuki
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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FUKAI NOZOMI
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate Sch
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WAGO Takehiko
Department of Clinical and Molecular Endocrinology Tokyo Medical and Dental University Graduate Scho
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UCHIMURA Isao
Department of Clinical and Molecular Endocrinology Tokyo Medical and Dental University Graduate Scho
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Hirata Yukio
Department Of Anatomy And Embryology Tokyo Metropolitan Institute For Neurosciences:(present)departm
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Fukai Nozomi
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Yoshimoto Takanobu
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University
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Doi Masaru
Department Of Clinical And Molecule Endocrinology Tokyo Medical And Dental University Graduate Schoo
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Hirata Yukio
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Hirata Yukio
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Yoshimoto Takanobu
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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