A Rare Case of ACTH-independent Macronodular Adrenal Hyperplasia Associated with Aldosterone-producing Adenoma
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概要
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A 52-year-old man was evaluated for incidentally discovered bilateral adrenal masses. He had drug-resistant hypertension but lacked Cushingoid features. Endocrinological tests revealed autonomous secretion of cortisol and aldosterone with suppressed plasma ACTH and renin activity. A selective adrenal venous sampling demonstrated aldosterone hypersecretion from the left adrenal vein. The clinical diagnosis of subclinical Cushings syndrome due to ACTH-independent macronodular adrenal hyperplasia (AIMAH) associated with primary aldosteronism was made, and he underwent left adrenalectomy; the resected adrenal lesion was consistent with the pathological diagnosis of AIMAH coexistent with aldosterone-producing adenoma (APA). This is a very rare case of AIMAH with concomitant unilateral APA, whose hypertension improved after surgery.
著者
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Izumiyama Hajime
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Sasano Hironobu
Department Of Anatomic Pathology Tohoku University School Of Medicine
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Hirata Yukio
Department Of Anatomy And Embryology Tokyo Metropolitan Institute For Neurosciences:(present)departm
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Yoshimoto Takanobu
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University
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Kato Masako
Department Of Chemistry Faculty Of Science Nara Women's University
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Hiraishi Kiichiro
Department Of Clinical And Molecular Endocrinology Tokyo Medical And Dental University Graduate Scho
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Izumiyama Hajime
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Japan
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Hayakawa Eri
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Japan
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Yoshimoto Takanobu
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Japan
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Hirata Yukio
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Japan
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Hiraishi Kiichiro
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Japan
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