HISTOLOGIC ORIGIN OF RAT OVARIAN CANCER INDUCED BY DIRECT APPLICATION OF 7,12-DIMETHYLBENZ(A)ANTHRACENE
スポンサーリンク
概要
- 論文の詳細を見る
A direct application of 7,12-dimethylbenz(a)anthracene (DMBA) to the ovary successfully produces an ovarian epithelial cancer in rat.To identify the histogenic process, the DMBA-treated rats were serially examined from the 15th to the 40th week following DMBA application. Furthermore, from the anticipated effect of estrogen on surface epithelial proliferation, the rats were put into an hyperestrogenic condition for immunohistochemical characterization of the tumor tissue.At the 20th week, the surface epithelial proliferations were seen to show remarkable multistratification with cellular pleomorphism.The proliferated surface cells began to infiltrate into the stroma to then form irregular gland structures. In immunoperoxidase stainings, both the adenocarcinoma cell and the surface cell has the same character in the immunohistochemical reaction for estradiol .On the base of these results, the induced cancer in rat was believed to have a similar histogenic process to the common epithelial tumors in human ovary.
- 社団法人日本産科婦人科学会の論文
- 1986-04-01
著者
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Sugiyama Toru
Department of Obstetrics and Gynecology, Iwate Medical University
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Yakushiji Michiaki
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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Nishida Takashi
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine a
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Yakushiji M
Kurume Univ. Fukuoka Jpn
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Yakushiji Michiaki
久留米大学 産婦人科
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Yakushiji Michiaki
久留米大学 第1病理
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Nishida T
Department Of Obstetrics Nad Gynecology Kurume University School Of Medicine
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KATABUCHI Hideki
Department of Obstetrics and Gynecology. School of Medicine, Kurume University
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KATO Toshi
Department of Obstetrics and Gynecology. School of Medicine, Kurume University
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Kamura Toshihatu
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Nishida Takashi
Department Of Biochemistry And Molecular Dentistry Okayama University Graduate School Of Medicine An
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Sugiyama Toru
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Kato Toshi
Department Of Obstetrics And Gynecology. School Of Medicine Kurume University
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Kato Toshi
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Sugiyama Toru
Department Of Chemistry Faculty Of Science And Technology Sophia University
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Kawagoe H
Kurume Univ. School Of Medicine Kurume Jpn
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Sugiyama Toru
Department Of Chemical Engineering Kyoto University
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KATABUCHI Hideki
Department of Obstetrics and Gynecology, Faculty of Medicine, Kurume University
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KATO TOSHI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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