CHARACTERIZATION OF TRANSPLANT GENERATIONS OF PRIMARY RAT ADENOCARCINOMA AND SOME CHEMOTHERAPEUTIC OBSERVATIONS
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概要
- 論文の詳細を見る
DMBA誘発ラット原発卵巣腺癌(concomitanttypeadenocarcinoma)を用い,同種(Wistar)幼若ラット背部皮下移植を行なうと,均一な充実性構造を示す未分化腺癌が得られる.抗癌剤としてCDDPを用いての実験化学療法では,原発腫瘍に比して全例に著名な腫瘍縮小効果が認められた.組織学的にも腫瘍辺縁部まで抗腫瘍効果が観察された.これら移植腫瘍は継代により変化せず,短期間(1ヵ月以内)で均一な腫瘍を同時に大量に作成でき,組織学的には,間質反応の少ない未分化腺癌で,またhypervascularであるため抗癌剤効果が顕著で容易にその効果判定ができたと考えられた。ヒト組織への類似性より卵巣腺癌の化学療法剤のスクリーニングモデルとしての価値を有していることが示唆され,さらに原発腫瘍モデルと組み合わせることにより,より進んだ実験化学療法が期待できると考えられた.
- 社団法人日本産科婦人科学会の論文
- 1987-04-01
著者
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Yakushiji Michiaki
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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Nishida Takashi
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine a
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USHIJIMA Kimio
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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KATABUCHI Hideki
Department of Obstetrics and Gynecology. School of Medicine, Kurume University
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KATO Toshi
Department of Obstetrics and Gynecology. School of Medicine, Kurume University
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NAKANAMI Masamichi
Department of Obstetrics and Gynecology, School of Medicine, Kurume University
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Ushijima Kimio
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Nishida Takashi
Department Of Biochemistry And Molecular Dentistry Okayama University Graduate School Of Medicine An
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Kato T
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Kato Toshi
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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杉山 透
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Nishida T
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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SHIBUE Kenichi
Department of Obstetrics and Gynecology, Faculty of Medicine, Kurume University
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Shibue Kenichi
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Kawagoe H
Kurume Univ. School Of Medicine Kurume Jpn
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Nakanami Masamichi
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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KATABUCHI Hideki
Department of Obstetrics and Gynecology, Faculty of Medicine, Kurume University
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KATO TOSHI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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USHIJIMA KIMIO
Department of Gynecology, Kurume University School of Medicine
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