Detection of Human Papillomavirus (HPV) Infections in Japanese Women with and without Abnormal Cervical Cytology by Dot Blot and Southern Blot Hybridization.
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概要
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The frequency of human papil lomavirus (HPV) was investigated in 245 Japanese women (100 showing normal cytology and 145 showing abnormal cytology). A previously presented method for the detection and typing of HPV DNA was used, where a dot blot test excluded samples that did not hybridize with HPV DNA. Positive samples were further analyzed by a southern blot procedure, to give the HPV type. A mixture of subgenomic probes of the types 6, 11, 16, 18, 31, 33 and 35 was used. HPV DNA was detected in only 2% (2/100) of patients without abnormal cytology. In patients with abnormal cytology, the frequency was 30% (43/145). HPV was detected in 100% (2/2) of the patients with condyloma acuminatum, 39% (26/66) of those with mild to moderate dysplasia, 44% (7/16) of those with severe dysplasia to carcinoma in situ, and 70% (7/10) of those with invasive carcinoma. Young women (20-29 yr.) had the highest HPV frequency (71%). HPV types 16 and 18 were found in 39% of the patients with mild to moderate dysplasia, in 71% of those with severe dysplasia to carcinoma in situ and in 86% of those with invasive carcinoma. These may be considered as high risk types for development to cancer. HPV type 31 may be considered as a moderate risk, as it was detected in 37% (16/43) of the patients. HPV types 6 and 11 were found in 100% of patients with condyloma acuminaum (2/2). To clarify the natural history of the HPV infection in the uterine cervix, it is necessary to conduct further studies.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Yakushiji Michiaki
Department Of Obstetrics And Gynecology Faculty Of Medicine Kurume University
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Tazaki Tamikazu
Department Of Obstetrics And Gynecology Kurume University School Of Medicine
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Tanaka Hiroshi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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HASUO YASUYUKI
Department of Obstetrics and Gynecology, Kurume University School of Medicine
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LINDH ELISABET
Department of Medical Microbiology , University of Lund, Malmo General Hospital and Medscand Laboratories
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YAKUSHIJI MICHIAKI
Department of Obstetrics and Gynecogy, Kurume University School of Medicine
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